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SKI2852
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Catalog No. T28796Cas No. 1346554-47-9
Alias SKI-2852
SKI2852 is an orally active, selective, and efficient 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, improving metabolic syndrome in diabetic mouse models.
SKI2852
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Purity: 99.89%
Catalog No. T28796Alias SKI-2852Cas No. 1346554-47-9
SKI2852 is an orally active, selective, and efficient 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, improving metabolic syndrome in diabetic mouse models.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $55 | In Stock | In Stock | |
| 5 mg | $129 | - | In Stock | |
| 10 mg | $208 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.89%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SKI2852 is an orally active, selective, and efficient 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor, improving metabolic syndrome in diabetic mouse models. |
| Targets&IC50 | HSD1 (Ms):1.6 nM, HSD1 (human):2.9 nM |
| In vitro | SKI2852, an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1), has IC 50 values of 2.9 nM and 1.6 nM for HEK293 cells transfected with human (h11βHSD1) and mouse 11βHSD1 (m11βHSD1), respectively. [1] |
| In vivo | Oral treatment with SKI2852 (12.5 mg/kg) significantly reduced weight gain in severely obese ob/ob mice. Results of SKI2852 (1, 3 or 10 mg/kg once daily for 8.5 weeks, administered orally) showed that all doses of SKI2852 significantly reduced FFA levels. Inhibition of 11βHSD1 by SKI2852 (12.5 mg/kg) may improve systemic and hepatic insulin sensitivity and reverse diabetic symptoms by at least partially inhibiting these gluconeogenic enzyme expression levels in DIO mice. [1] |
| Synonyms | SKI-2852 |
| Molecular Weight | 543.65 |
| Formula | C27H34FN5O4S |
| Cas No. | 1346554-47-9 |
| Smiles | N(C(=O)C1=NC(=NC=C1)N2[C@H](C)CN(CC2)C3=C(F)C=C(S(C)(=O)=O)C=C3)[C@@H]4[C@]5(CC6(O)C[C@@]4(CC(C5)C6)[H])[H] |
| Relative Density. | 1.44 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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