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Hypericin
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Catalog No. T6S0923Cas No. 548-04-9
Alias Hypericine, Cyclosan
Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities.
Hypericin
Copy Product Info🥰Excellent
Purity: 99.51%
Catalog No. T6S0923Alias Hypericine, CyclosanCas No. 548-04-9
Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $52 | In Stock | In Stock | |
| 5 mg | $129 | In Stock | In Stock | |
| 10 mg | $192 | In Stock | In Stock | |
| 25 mg | $379 | In Stock | In Stock | |
| 50 mg | $559 | In Stock | In Stock | |
| 100 mg | $783 | In Stock | In Stock | |
| 500 mg | $1,590 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $143 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.51%
Color:Purple to Black
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Product Introduction
Hypericin AI Summary
Hypericin exhibits a broad spectrum of bioactivities across various biological targets. It inhibits HIV-1 integrase, specifically at the 3''-preprocessing step, with an IC50 of 10000 nM, indicating its potency against the enzyme related to HIV-1. The compound has a partition coefficient (logP) of 5.02, shows antioxidant potential (reducing activity against DPPH with kDPPH = 3.66 M-1 s-1), and peroxidant properties (malondialdehyde and deoxyribose release ratio < 0.3).
In cytotoxicity assays, Hypericin exhibits antiproliferative activity against HaCaT cells (IC50 = 1700 nM) and significant cytotoxicity at 2 µM (LDH release = 159 MU). It also displays antidepressant activity in rats, binding to the dopamine D3 receptor (Ki = 34.5 nM) and inhibiting CRF1 receptor (IC50 = 300 nM), while reducing CRF mRNA and 5HT1A receptor mRNA expression. Additionally, it moderately inhibits CYP3A4 enzyme activity.
The compound demonstrates antiviral activity against various viruses, including equine infectious anemia virus (EIAV) and SARS-CoV-2, with potent inhibition rates and IC50 values (SARS-CoV-2 IC50 = 250 nM). It also shows activity against Streptococcus mutans with a MIC of 250 µg/mL and ability to inhibit biofilm formation and decrease membrane fluidity.
Furthermore, Hypericin inhibits multiple enzymes, including Hepatitis C virus NS3 helicase (IC50 = 3000 nM), sGC (IC50 = 200-700 nM), and HDAC6 (high inhibition percentages in various assays). It affects metabolic enzymes such as rat liver cytosolic TrxR1 (IC50 = 198000 nM), mitochondrial TrxR2 (IC50 = 49000 nM), and yeast glutathione reductase (IC50 = 3670 nM). The compound also inhibits acetylcholinesterase and butyrylcholinesterase.
Additionally, it shows bioactivity in decreasing cellular cGMP levels in frog atrial myocytes at 4 µM, inhibiting alpha-synuclein filament formation (IC50 = 7500 nM), and maintaining stability with a human half-life of 42 hours, clearance rate of 0.13 mL/min/kg, and volume of distribution at steady state of 0.25 L/kg.
Overall, Hypericin represents a multipotent bioactive compound with potential therapeutic applications across various diseases, including viral infections, cancer, neurological disorders, and more..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Hypericin (Cyclosan) is a natural anthraquinone compound, an extract of Hypericum perforatum, which inhibits PKC, MAO, dopamine-beta-hydroxylase, reverse transcriptase, telomerase, and CYP, etc. Hypericin exhibits antimicrobial, antiviral, antitumor, and antidepressant activities. |
| Targets&IC50 | Y2 receptor:3-4 μM, Hvr100-6:22.9 ± 1.4 mM, NPYY1 receptor:3-4 μM, HeLa cells:17.2 ± 3.3 mM, melanocytes:3.5 μM (LD50), Fibroblasts:1.75 μM (LD50), keratinocytes:4 μM (LD50), Tyrosine kinase:7.5 μM, MCF-7 cells:5 µg/mL (LD50) |
| In vitro | METHODS: Erythrocytes were treated with Bioymifi (10-100 µM) for 24 h. Flow cytometry was used to characterize the hemolytic and bactericidal properties of Bioymifi and the potential molecular mechanisms. RESULTS: Bioymifi exerted a dose-responsive, calcium-independent hemolytic effect, reduced erythrocyte hemoglobin, and significantly increased membrane-bound protein V, Fluo4, and DCF-positive cells, as well as a dual effect on forward and lateral light scattering. [1] METHODS: Neonatal rat ventricular myocytes (nrvm) were treated with Bioymifi (10 µM) for 24 h, and the expression levels of target proteins were detected by Western Blot. RESULTS: The expression of DR5 was higher than that of NRVF in Bioymifi-treated nrvm. [2] |
| In vivo | METHODS: To investigate the role of DR5 activation in the heart, Bioymifi (5 mg/kg/d) micro-osmotic pump was administered to C57BL/6 mice once daily for two weeks. RESULTS: Bioymifi administration resulted in hypertrophy at the level of cardiac organs and cardiomyocytes, but did not affect cardiomyocyte death or cardiac fibrosis. [2] |
| Synonyms | Hypericine, Cyclosan |
| Molecular Weight | 504.44 |
| Formula | C30H16O8 |
| Cas No. | 548-04-9 |
| Smiles | Cc1cc(O)c2c3c1c1c(C)cc(O)c4c1c1c3c3c(c(O)cc(O)c3c2=O)c2c(O)cc(O)c(c12)c4=O |
| Relative Density. | 1.915 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight,keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||
| Solubility Information | Ethanol: 5 mg/mL (9.91 mM), Heating is recommended.  DMSO: 100 mg/mL (198.24 mM), Sonication is recommended. Propylene glycol: 2.52 mg/mL (5 mM), Sonication is recommended. | |||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.25 mg/mL (2.48 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||
Solution Preparation Table | ||||||||||||||||
Propylene glycol/Ethanol/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
TyrosineKinasestyrosine kinasestelomerase and CYPTelomeraseReverse TranscriptaseProtein kinase CPKCmonoaminoxidaseMonoamine OxidasemelanocytesMAOkeratinocytesInhibitorinhibitInfluenzaVirusInfluenza VirusHypericumHypericinfibroblastsDopamine β-monooxygenaseDopamine β-hydroxylaseDopamine beta-monooxygenaseDopamine beta-hydroxylaseCytochrome P450CYPsApoptosisantiviral activityantiviralantitumor activityantidepressive activityAntibioticantibacterial
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