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DMP-543

Name: DMP-543
Brand: TargetMol
SKU: T15143
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15143Cas No. 160588-45-4

Alias XR-543

DMP-543 (XR-543) is a KV7 channel blocker that enhances neurotransmitter release.

DMP-543

🥰Excellent

Purity: 99.74%

Catalog No. T15143Alias XR-543Cas No. 160588-45-4

DMP-543 (XR-543) is a KV7 channel blocker that enhances neurotransmitter release.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$34	In Stock	In Stock
25 mg	$68	In Stock	In Stock
50 mg	$111	In Stock	In Stock
100 mg	$180	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.74%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	DMP-543 (XR-543) is a KV7 channel blocker that enhances neurotransmitter release.
Targets&IC50	[3H]-Ach:700 nM(EC50)
In vitro	DMP-543 (XR-543) is a KV7 channel blocker, also acts as a potent neurotransmitter release enhancer.[1][2] DMP-543 enhances [3H]ACh release in rat brain slices (EC50: 700 nM).[2]
Synonyms	XR-543

Chemical Properties

Molecular Weight	412.43
Formula	C₂₆H₁₈F₂N₂O
Cas No.	160588-45-4
Smiles	Fc1cc(CC2(Cc3ccnc(F)c3)c3ccccc3C(=O)c3ccccc23)ccn1
Relative Density.	1.319 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (218.2 mM ), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4247 mL	12.1233 mL	24.2465 mL	121.2327 mL
5 mM	0.4849 mL	2.4247 mL	4.8493 mL	24.2465 mL
10 mM	0.2425 mL	1.2123 mL	2.4247 mL	12.1233 mL
20 mM	0.1212 mL	0.6062 mL	1.2123 mL	6.0616 mL
50 mM	0.0485 mL	0.2425 mL	0.4849 mL	2.4247 mL
100 mM	0.0242 mL	0.1212 mL	0.2425 mL	1.2123 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc