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BI-4464

Name: BI-4464
Brand: TargetMol
SKU: T5480
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T5480Cas No. 1227948-02-8

BI-4464, a highly selective ATP-competitive inhibitor of PTK2/FAK, exhibits an IC50 of 17 nM and serves as a PTK2 ligand for PROTAC (Proteolysis Targeting Chimera).

BI-4464

🥰Excellent

Purity: 97.43%

Catalog No. T5480Cas No. 1227948-02-8

BI-4464, a highly selective ATP-competitive inhibitor of PTK2/FAK, exhibits an IC50 of 17 nM and serves as a PTK2 ligand for PROTAC (Proteolysis Targeting Chimera).

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$74	In Stock
10 mg	$118	In Stock
25 mg	$213	In Stock
50 mg	$322	In Stock
100 mg	$449	In Stock
200 mg	$633	In Stock

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Batch Information

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Purity:97.43%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	BI-4464, a highly selective ATP-competitive inhibitor of PTK2/FAK, exhibits an IC50 of 17 nM and serves as a PTK2 ligand for PROTAC (Proteolysis Targeting Chimera).
Targets&IC50	PTK2/FAK:17 nM

Chemical Properties

Molecular Weight	555.55
Formula	C₂₈H₂₈F₃N₅O₄
Cas No.	1227948-02-8
Smiles	O(C1=C2C(CCC2=O)=CC=C1)C=3C(C(F)(F)F)=CN=C(NC4=C(OC)C=C(C(NC5CCN(C)CC5)=O)C=C4)N3
Relative Density.	1.41 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (30.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8000 mL	9.0001 mL	18.0002 mL	90.0009 mL
5 mM	0.3600 mL	1.8000 mL	3.6000 mL	18.0002 mL
10 mM	0.1800 mL	0.9000 mL	1.8000 mL	9.0001 mL
20 mM	0.0900 mL	0.4500 mL	0.9000 mL	4.5000 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc