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TIQ-A

Name: TIQ-A
Brand: TargetMol
SKU: T50098
Price: 46 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T50098Cas No. 420849-22-5

TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.

TIQ-A

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Purity: 99.74%

Catalog No. T50098Cas No. 420849-22-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$46	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$173	In Stock	In Stock
25 mg	$323	In Stock	In Stock
50 mg	$461	In Stock	In Stock
100 mg	$592	In Stock	In Stock
200 mg	$818	-	In Stock
1 mL x 10 mM (in DMSO)	$103	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.74%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

TIQ-A AI Summary

TIQ-A is a potent inhibitor of various poly(ADP-ribose) polymerases (PARPs). It exhibits significant inhibition of ARTD6 and ARTD5 with IC50 values of approximately 24.0 nM and 200.0 nM, respectively, and bovine ARTD1 with an IC50 of 450.0 nM. The compound also effectively inhibits TNKS2 with an IC50 of 24.0 nM and PARP15 with an IC50 of 230.0 nM. In contrast, it shows weak inhibition of PARP1 and PARP2, with IC50 values of 900.0 nM and 600.0 nM, respectively, and minimal inhibition of tankyrase-1 (IC50 > 100,000.0 nM). TIQ-A additionally demonstrates antiviral properties, inhibiting SARS-CoV-2 3CL-Pro protease at 20 µM with an inhibition rate of 17.57% and mitigating SARS-CoV-2 induced cytotoxicity in VERO-6 cells at a concentration of 10 µM. However, it exhibits limited solubility in aqueous solutions at pH 7.4 and 23°C, with solubility less than 100.0 µg/mL. These properties highlight its potential therapeutic applications in both cancer and antiviral treatments..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	TIQ-A is a PARP1 inhibitor which involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis.
Targets&IC50	PARP14:>10 μM, TNKS2:24 nM, PARP10:>10 μM, PARP2:210 nM, PARP15:230 nM

Chemical Properties

Molecular Weight	201.24
Formula	C₁₁H₇NOS
Cas No.	420849-22-5
Smiles	O=c1[nH]c2sccc2c2ccccc12
Relative Density.	1.358 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (273.31 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.9692 mL	24.8460 mL	49.6919 mL	248.4596 mL
5 mM	0.9938 mL	4.9692 mL	9.9384 mL	49.6919 mL
10 mM	0.4969 mL	2.4846 mL	4.9692 mL	24.8460 mL
20 mM	0.2485 mL	1.2423 mL	2.4846 mL	12.4230 mL
50 mM	0.0994 mL	0.4969 mL	0.9938 mL	4.9692 mL
100 mM	0.0497 mL	0.2485 mL	0.4969 mL	2.4846 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc