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Bafilomycin B1
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Catalog No. T10455Cas No. 88899-56-3
Bafilomycin B1 is a macrolide antibiotic discovered in Streptomyces gresuis. It exhibits neuroprotective effects and V-ATPase inhibitory activity, and can also inhibit LDL-induced lipid droplet accumulation.
Bafilomycin B1
😃Good
Catalog No. T10455Cas No. 88899-56-3
Bafilomycin B1 is a macrolide antibiotic discovered in Streptomyces gresuis. It exhibits neuroprotective effects and V-ATPase inhibitory activity, and can also inhibit LDL-induced lipid droplet accumulation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 100 μg | $168 | - | In Stock | |
| 5 mg | $2,039 | 35 days | 35 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Bafilomycin B1 is a macrolide antibiotic discovered in Streptomyces gresuis. It exhibits neuroprotective effects and V-ATPase inhibitory activity, and can also inhibit LDL-induced lipid droplet accumulation. |
| In vitro | Bafilomycin B1 (1 nM, 24 h) significantly suppressed chloroquine-induced death in cerebellar granule neurons[1]. Bafilomycin B1 (0.1-10 nM, 48 h) did not induce cell death or apoptosis in SH-SY5Y cells at concentrations ≤ 1 nM, and significantly attenuated chloroquine-induced cell death when 50 μM chloroquine was added [2]. Bafilomycin B1 (10–40 nM, 37°C) significantly inhibited surface binding, intracellular accumulation, and degradation of oxidized 125I-LDL in J774 cells [3]. |
| In vivo | In homozygous nematodes overexpressing human wild-type α-synuclein in dopaminergic neurons, Bafilomycin B1 (50–150 μg/mL, 24 hours) provided significant protection against α-synuclein-induced dopaminergic degeneration [2]. |
| Molecular Weight | 816 |
| Formula | C44H65NO13 |
| Cas No. | 88899-56-3 |
| Smiles | [H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](OC(=O)\C=C\C(=O)NC2=C(O)CCC2=O)[C@H](C)[C@H](O1)C(C)C |
| Relative Density. | 1.22 g/cm3 |
| Color | Yellow |
| Appearance | Solid |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80.00 mg/mL (98.04 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO (stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(stock solution concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyThe above example illustrates how to use "In Vivo Formulation Calculator" and does not represent a recommended formulation for any specific compound. Please select an appropriate dissolution method based on your experimental animals and route of administration.
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