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Bafilomycin B1

Name: Bafilomycin B1
Brand: TargetMol
SKU: T10455
Price: 168 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10455Cas No. 88899-56-3

Bafilomycin B1 is a macrolide antibiotic discovered in Streptomyces gresuis. It exhibits neuroprotective effects and V-ATPase inhibitory activity, and can also inhibit LDL-induced lipid droplet accumulation.

Bafilomycin B1

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Catalog No. T10455Cas No. 88899-56-3

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 μg	$168	-	In Stock
5 mg	$2,039	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Appearance:Solid

Color:Yellow

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Product Introduction

Bioactivity

Description	Bafilomycin B1 is a macrolide antibiotic discovered in Streptomyces gresuis. It exhibits neuroprotective effects and V-ATPase inhibitory activity, and can also inhibit LDL-induced lipid droplet accumulation.
In vitro	Bafilomycin B1 (1 nM, 24 h) significantly suppressed chloroquine-induced death in cerebellar granule neurons[1]. Bafilomycin B1 (0.1-10 nM, 48 h) did not induce cell death or apoptosis in SH-SY5Y cells at concentrations ≤ 1 nM, and significantly attenuated chloroquine-induced cell death when 50 μM chloroquine was added [2]. Bafilomycin B1 (10–40 nM, 37°C) significantly inhibited surface binding, intracellular accumulation, and degradation of oxidized 125I-LDL in J774 cells [3].
In vivo	In homozygous nematodes overexpressing human wild-type α-synuclein in dopaminergic neurons, Bafilomycin B1 (50–150 μg/mL, 24 hours) provided significant protection against α-synuclein-induced dopaminergic degeneration [2].

Chemical Properties

Molecular Weight	816
Formula	C₄₄H₆₅NO₁₃
Cas No.	88899-56-3
Smiles	[H][C@@]1(OC(=O)\C(OC)=C\C(\C)=C\[C@@H](C)[C@@H](O)[C@@H](C)C\C(C)=C\C=C\[C@@H]1OC)[C@@H](C)[C@@H](O)[C@H](C)[C@@]1(O)C[C@@H](OC(=O)\C=C\C(=O)NC2=C(O)CCC2=O)[C@H](C)[C@H](O1)C(C)C
Relative Density.	1.22 g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80.00 mg/mL (98.04 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.2255 mL	6.1275 mL	12.2549 mL	61.2745 mL
5 mM	0.2451 mL	1.2255 mL	2.4510 mL	12.2549 mL
10 mM	0.1225 mL	0.6127 mL	1.2255 mL	6.1275 mL
20 mM	0.0613 mL	0.3064 mL	0.6127 mL	3.0637 mL
50 mM	0.0245 mL	0.1225 mL	0.2451 mL	1.2255 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc