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SMCC-DM1

Name: SMCC-DM1
Brand: TargetMol
SKU: T16899
Price: 97 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16899Cas No. 1228105-51-8

Alias DM1-SMCC

SMCC-DM1 is a drug-coupler coupler consisting of a potent microtubule disrupter, DM1, and a coupler, SMCC, for the preparation of antibody-drug couplers.

SMCC-DM1

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Purity: 99.25%

Catalog No. T16899Alias DM1-SMCCCas No. 1228105-51-8

SMCC-DM1 is a drug-coupler coupler consisting of a potent microtubule disrupter, DM1, and a coupler, SMCC, for the preparation of antibody-drug couplers.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$97	In Stock	In Stock
5 mg	$148	In Stock	In Stock
10 mg	$274	In Stock	In Stock
25 mg	$468	In Stock	In Stock
50 mg	$688	In Stock	In Stock
100 mg	$977	In Stock	In Stock
200 mg	$1,320	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.25%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SMCC-DM1 is a drug-coupler coupler consisting of a potent microtubule disrupter, DM1, and a coupler, SMCC, for the preparation of antibody-drug couplers.
In vitro	METHODS: The antiproliferative effects of SMCC-DM1, LDs 17 and LDs 18) on two cell lines, HCC-1954 (her2 positive) and MDA-MB-468 (her2 negative), were evaluated using Promega cell titer-glo fluorescence cell viability assay. RESULTS SMCC-DM1 inhibited the proliferation of HCC1954 and MDA-MB-468 cells with IC50 of 17.2 and 49.9 nM.[1]
Synonyms	DM1-SMCC

Chemical Properties

Molecular Weight	1072.61
Formula	C₅₁H₆₆ClN₅O₁₆S
Cas No.	1228105-51-8
Smiles	CO[C@@H]1\C=C/C=C(C)\Cc2cc(OC)c(Cl)c(c2)N(C)C(=O)C[C@H](OC(=O)[C@H](C)N(C)C(=O)CCSC2CC(=O)N(CC3CCC(CC3)C(=O)ON3C(=O)CCC3=O)C2=O)[C@]2(C)O[C@H]2[C@H](C)[C@@H]2C[C@@]1(O)NC(=O)O2
Relative Density.	1.41 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 75 mg/mL (69.92 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (1.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.9323 mL	4.6615 mL	9.3231 mL	46.6153 mL
5 mM	0.1865 mL	0.9323 mL	1.8646 mL	9.3231 mL
10 mM	0.0932 mL	0.4662 mL	0.9323 mL	4.6615 mL
20 mM	0.0466 mL	0.2331 mL	0.4662 mL	2.3308 mL
50 mM	0.0186 mL	0.0932 mL	0.1865 mL	0.9323 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc