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Anti-CD146/MCAM Antibody (6W862)
😃Good
Catalog No. TMAC-00660
Alias S-endo 1 endothelial-associated antigen, Melanoma-associated antigen MUC18, Melanoma-associated antigen A32, Melanoma cell adhesion molecule, Cell surface glycoprotein P1H12, Cell surface glycoprotein MUC18
Anti-CD146/MCAM Antibody (6W862) is a Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (6W862) can be used in FCM,ICC,IF,IHC,WB.
Anti-CD146/MCAM Antibody (6W862)
Anti-CD146/MCAM Antibody (6W862)
😃Good
Catalog No. TMAC-00660Alias S-endo 1 endothelial-associated antigen, Melanoma-associated antigen MUC18, Melanoma-associated antigen A32, Melanoma cell adhesion molecule, Cell surface glycoprotein P1H12, Cell surface glycoprotein MUC18
Anti-CD146/MCAM Antibody (6W862) is a Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (6W862) can be used in FCM,ICC,IF,IHC,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $298 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD146/MCAM Antibody (6W862) is a Rabbit antibody targeting CD146/MCAM. Anti-CD146/MCAM Antibody (6W862) can be used in FCM,ICC,IF,IHC,WB. |
| Synonyms | S-endo 1 endothelial-associated antigen, Melanoma-associated antigen MUC18, Melanoma-associated antigen A32, Melanoma cell adhesion molecule, Cell surface glycoprotein P1H12, Cell surface glycoprotein MUC18 |
| Ig Type | IgG |
| Clone | 6W862 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of CD146 on SiHa cell using anti-CD146 antibody at 1/500 dilution. 2. Immunohistochemical analysis of paraffin-embedded rat brain tissue using anti-CD146 antibody. Counter stained with hematoxylin. 3. Immunohistochemical analysis of paraffin-embedded human tonsil tissue using anti-CD146 antibody. Counter stained with hematoxylin. 4. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-CD146 antibody. Counter stained with hematoxylin. 5. ICC staining CD146 in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 6. ICC staining CD146 in HUVEC cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 7. Flow cytometric analysis of HUVEC cells with CD146 antibody at 1/100 dilution (red) compared with an unlabelled control (cells without incubation with primary antibody; black). Alexa Fluor 488-conjugated goat anti-rabbit IgG was used as the secondary antibody.        |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC: 1:100-500; FCM: 1:50-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The tumorigenic and metastatic phenotype of melanoma cells correlates well with an increased expression of cell-cell and cell-matrix adhesion receptors. The human Mel-CAM gene encodes a transmembrane glycoprotein, also designated MCAM, MUC18 or CD146, that belongs to the immunoglobulin superfamily and functions as a Ca2+-independent cell adhesion molecule. The deduced human sequence of 603 amino acids consists of a signal peptide, five immunoglobulin-like domains, a transmembrane region and a short cytoplasmic tail. Mel-CAM expression is restricted to advanced primary and metastatic melanomas and to cell lines of the neuroectodermal lineage, but not normal melanocytes. Mel-CAM is found on 80% of advanced primary human mela-nomas and correlates well with development of metastatic disease. Mel-CAM activation initiates an outside-in signaling pathway that involves the protein tyrosine kinases Fyn, FAK and paxillin. Mel-CAM influences the dynamics of Actin cytoskeleton rearrangement and is essential for the maintenance of thymic architecture and function. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 72 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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