Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound also hampers the proliferation of TNBC cells and the growth of TNBC xenograft tumors [1].
Pack Size | Availability | Price/USD | Quantity |
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50 mg | Inquiry | Inquiry |
Description | PARP-1/2-IN-2-IN-1 (Compound 12e) effectively inhibits PARP1/2 and CDK12 with IC 50 values of 34 nM, 30 nM, and 285 nM respectively, impairing DNA damage repair and inducing cell cycle arrest and apoptosis. This compound also hampers the proliferation of TNBC cells and the growth of TNBC xenograft tumors [1]. |
Molecular Weight | 610.41 |
Formula | C25H23IN8O3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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PARP-1/2-IN-2 Chromatin/Epigenetic DNA Damage/DNA Repair PARP inhibitor inhibit