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DL-Mevalonolactone

Name: DL-Mevalonolactone
Brand: TargetMol
SKU: T1353
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1353Cas No. 674-26-0

Alias Mevalonolactone

DL-Mevalonolactone, a human endogenous metabolite, is the δ-lactone form of mevalonate, a precursor of the mevalonate pathway. It reduces mitochondrial membrane potential (∆Ψm), Ca2+ retention and NAD(P)H levels in the brain, and also induces mitochondrial swelling.DL-Mevalonolactone induces inflammation and oxidative stress, and reduces mitochondrial membrane potential.

DL-Mevalonolactone

🥰Excellent

Purity: 99.88%

Catalog No. T1353Alias MevalonolactoneCas No. 674-26-0

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$41	In Stock	In Stock
200 mg	$60	-	In Stock
1 mL x 10 mM (in DMSO)	$45	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	DL-Mevalonolactone, a human endogenous metabolite, is the δ-lactone form of mevalonate, a precursor of the mevalonate pathway. It reduces mitochondrial membrane potential (∆Ψm), Ca2+ retention and NAD(P)H levels in the brain, and also induces mitochondrial swelling.DL-Mevalonolactone induces inflammation and oxidative stress, and reduces mitochondrial membrane potential.
Synonyms	Mevalonolactone

Chemical Properties

Molecular Weight	130.14
Formula	C₆H₁₀O₃
Cas No.	674-26-0
Smiles	CC1(O)CCOC(=O)C1
Relative Density.	1.189 g/cm3

Storage & Solubility Information

Storage

Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (345.78 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (15.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	7.6840 mL	38.4202 mL	76.8403 mL	384.2016 mL
5 mM	1.5368 mL	7.6840 mL	15.3681 mL	76.8403 mL
10 mM	0.7684 mL	3.8420 mL	7.6840 mL	38.4202 mL
20 mM	0.3842 mL	1.9210 mL	3.8420 mL	19.2101 mL
50 mM	0.1537 mL	0.7684 mL	1.5368 mL	7.6840 mL
100 mM	0.0768 mL	0.3842 mL	0.7684 mL	3.8420 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc