Shopping Cart

Your shopping cart is currently empty

Pteropodine

Name: Pteropodine
Brand: TargetMol
SKU: TN2116
Price: 108 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Uncarine C) Copy Product Info

🥰Excellent

Synonyms: Uncarine C

Catalog No. TN2116 Copy Product Info

Purity: 99.77%

🥰Excellent

Pteropodine (Uncarine C) is a monoterpenoid indole alkaloid belonging to the class of natural products with a five-ring structure. It acts as a positive allosteric modulator of M1 muscarinic acetylcholine receptors and 5-HT2 serotonin receptors, concentration-dependently enhancing receptor signaling responses induced by agonists. Pteropodine exhibits immunomodulatory, anti-inflammatory, and neuroprotective activities and is commonly used in research on natural medicines and bioactive plant compounds.

Cas No. 5629-60-7

Pack Size	Price	USA Stock	Global Stock
1 mg	$108	-	In Stock
5 mg	$279	-	In Stock
10 mg	$446	-	In Stock
25 mg	$723	-	In Stock
50 mg	$996	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Batch Information

Select Batch

Purity:99.77%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Pteropodine (Uncarine C) is a monoterpenoid indole alkaloid belonging to the class of natural products with a five-ring structure. It acts as a positive allosteric modulator of M1 muscarinic acetylcholine receptors and 5-HT2 serotonin receptors, concentration-dependently enhancing receptor signaling responses induced by agonists. Pteropodine exhibits immunomodulatory, anti-inflammatory, and neuroprotective activities and is commonly used in research on natural medicines and bioactive plant compounds.
In vitro	Pteropodine and isoPteropodine (1–30 μM) do not induce membrane currents on their own, but they can concentration-dependently and reversibly enhance the current responses induced by acetylcholine and 5-HT, with the maximum effect observed at 30 μM [1]. Pteropodine (30 μM) increased the acetylcholine-induced current response 2.7-fold, with an EC50 of 9.52 μM. Pteropodine (30 μM) increased the 5-HT-induced current response 2.4-fold, with an EC50 of 13.5 μM. Pteropodine (10 μM) and isoPteropodine (10 μM) significantly reduced the EC50 values for acetylcholine and 5-HT, but did not affect the maximum current responses induced by either agonist [1].
Synonyms	Uncarine C

Chemical Properties

Molecular Weight	368.43
Formula	C₂₁H₂₄N₂O₄
Cas No.	5629-60-7
Smiles	O=C1[C@@]2([C@]3(N(CC2)C[C@@]4([C@](C3)(C(C(OC)=O)=CO[C@H]4C)[H])[H])[H])C=5C(N1)=CC=CC5
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Keep away from moisture, Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc