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Anti-Contactin 1 Antibody (3L885)
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Catalog No. TMAY-00732
Alias usl, F3cam, contactin 1, CNTN, AW495098
Anti-Contactin 1 Antibody (3L885) is a Mouse antibody targeting Contactin 1. Anti-Contactin 1 Antibody (3L885) can be used in ELISA.
Anti-Contactin 1 Antibody (3L885)
Anti-Contactin 1 Antibody (3L885)
😃Good
Catalog No. TMAY-00732Alias usl, F3cam, contactin 1, CNTN, AW495098
Anti-Contactin 1 Antibody (3L885) is a Mouse antibody targeting Contactin 1. Anti-Contactin 1 Antibody (3L885) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $199 | 7-10 days |
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Chemical Properties
| Description | Anti-Contactin 1 Antibody (3L885) is a Mouse antibody targeting Contactin 1. Anti-Contactin 1 Antibody (3L885) can be used in ELISA. |
| Alias | usl, F3cam, contactin 1, CNTN, AW495098 |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 3L885 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CNTN1 (rhCNTN1; TMPY-00720; Met1-Ser993; NP_001834.2). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2 (TAG-1), Contactin-3 (BIG-1), BIG-2, Contactin-5 (NB-2) and NB-3. Since their identification in the late 1980s, Contactin-1 and Contactin-2 have been studied extensively. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. In contrast, the function of the other four members of this subgroup remained unknown until recently. Contactin-1 is a cell surface adhesion molecule that is normally expressed by neurons and oligodendrocytes. Particularly high levels of Contactin-1 are present during brain development. Contactin-1 and Contactin-2 are differentially expressed in a number of neuronal tissues during development, and they interact with several ligands including Nr-CAM, L1, NCAM, neurocan, phosphacan, and tenascin. As a cell adhesion molecule, Contactin-1 plays a role in the formation of axon connections in the developing nervous system. It was demonstrated that Contactin-1 participates in signal pathways via its association with Contactin-associated protein (CNTNAP1), receptor protein tyrosine phosphatase beta (RPTPb) and NOTCH1. Contactin-1 is also involved in paranodal axo-glial junction formation and oligodendrocytes generation. Furthermore, studies indicated that Contactin-1 functions importantly in the invasion and metastasis of lung adenocarcinoma cells. Contactin-1 may also significantly influence the functional expression and distribution of Na+channels in neurons. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CNTN1 protein (TMPY-00720) |
| Antigen Species | Human |
| Biology Area | Notch Pathway |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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