iκbα

BAY 11-7082 (BAY 11-7821) is an NF-κB inhibitor that suppresses TNFα-induced IκBα phosphorylation (IC50=10 μM) and also inhibits the ubiquitin-specific proteases USP7 and USP21 (IC50=0.19/0.96 μM).

Cyclo(L-Pro-L-Val), a 2,5-diketopiperazine extracted from the fruits of Mycobacterium chiliolyticum AZ2 and Mycobacterium leprae, possesses anti-inflammatory activity and virulence activity against phytopathogenic microorganisms (e.g., R. fascians LMG 3605) and inhibits Gram-positive plant pathogens.Cyclo(L-Pro-L-Val) significantly inhibited IKKα phosphorylation and IκBα and NF-κB activation as well as iNOS and COX-2 activation in a concentration Cyclo(L-Pro-L-Val) significantly inhibited the phosphorylation of IKKα, IKKβ, IκBα, and NF-κB, as well as the activation of iNOS and COX-2 in a concentration-dependent manner, and is a potential therapeutic agent for the treatment of inflammation-related diseases.

Bay 11-7085 can irreversibly inhibit the IκBα phosphorylation induced by TNFα (IC50: 10 μM).

GS143 is a selective IκBα ubiquitination inhibitor with an IC50 of 5.2 μM for SCFβTrCP1-mediated IκBα ubiquitylation. It suppresses NF-κB activation and transcription of target genes without inhibiting proteasome activity. GS143 has anti-asthm[atic] properties.

Mexiletine hydrochloride (KOE-1173 hydrochloride) is a voltage-gated sodium channel blocker and a Class IB antiarrhythmic drug. Mexiletine hydrochloride exerts antiarrhythmic effects by inhibiting sodium current in myocardial cells, thereby reducing the rise rate of cardiac action potential (phase 0) and reducing the automaticity of Purkinje fibers.

DMT-dG(ib) Phosphoramidite can be used to synthesize DNA.

Apidaecin IB is an insect antimicrobial peptide, with MIC values of 8 μM for E. coli (O18K1H7, ML35 and ATCC 25922).

Apidaecin IB acetate is an insect antibacterial peptide. The minimum concentration of apidaecin IB acetate against Escherichia coli (E. coli ML35, o18k1h7 and ATCC 25922) is 8 μM.

(S)-IB-96212 (compound 4) is an oligomycin derivative that inhibits the MurD2 reaction but does not affect the MurL reaction. This compound specifically targets and inhibits a bypass pathway of peptidoglycan biosynthesis. Additionally, (S)-IB-96212 exhibits weak inhibition of the MurD reaction.

Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase [NQO1] and is utilized in anticancer research.

1. Picfeltarraenin IB and Picfeltarraenin IA displayes no cytotoxic activity in vitro human tumor cell line panel.

Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs.

Namodenoson (2-Cl-IB-MECA) is an adenosine A3 receptor agonist.

Piclidenoson (CF-101), a selective agonist of adenosine A3 receptor(EC50 values of 0.11 μM), induces robust anti-inflammatory effect in psoriasis patients.

Gemcitabine-ibandronate (GEM–IB), a conjugate of gemcitabine (GEM)-5'-phosphate with ibandronate (IB), exhibits efficacy both as a monotherapy and synergistically with Docetaxel (DTX), resulting in diminished tumor burden, maintained bone structure, and enhanced survival in a murine osteosarcoma (OS) model [1].

Anti-TNFR2/CD120b/TNFR1B Antibody (6I44) is a Rabbit IgG monoclonal antibody targeting Mouse TNFR2/CD120b/TNFR1B.

Picfeltarraenin IB (Standard) is a reference standard for research and analysis in studies involving Picfeltarraenin IB. 1. Picfeltarraenin IB and Picfeltarraenin IA displayes no cytotoxic activity in vitro human tumor cell line panel.

Escin IB (Standard) is a reference standard for research and analysis in studies involving Escin IB. Escin Ib inhibits gastric emptying, at least in part, mediated by capsaicin-sensitive sensory nerves, to stimulate the synthesis and/or release of dopamine, to act through central dopamine2 receptor, which in turn causes the release of PGs.

Isoescin IB (Standard) is a reference standard for research and analysis in studies involving Isoescin IB. Isoescin IB is a natural product from Aesculus hippocastanum L. Isoescin IB and Escin IB are the chief active ingredients in escin.

Pristinamycin IB (Ostreogrycin B2) is a lipopetide antibiotic effective against Gram-positive bacteria.

Isoescin IB is a natural product from Aesculus hippocastanum L.

Chikusetsusaponin Ib (Chikusetsu saponin Ib) is an inhibitor of AChE and can be used in studies about anti-Alzheimer's diseases.

Cinchonain Ib is isolated from Eriobotrya japonica leaves. Cinchonain Ib has an insulinotropic effect and can be used for stidies about managing type 2 diabetes.

Griffonia Simplicifolia Lectin I Isolectin B4 (Biotinylated) is a plant-derived lectin that can specifically interact with biomolecules such as polysaccharides and peptides, and is therefore used as a probe tool in biological analysis. Griffonia Simplicifolia Lectin I Isolectin B4 (Biotinylated) is also a substance that can be used as a biomaterial or organic compound in life science research.