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Anti-Mouse ICOSL/CD275 Antibody (HK5.3)
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Catalog No. T9901A-1979
Anti-Mouse ICOSL/CD275 Antibody (HK5.3) is a monoclonal antibody against mouse ICOSL/CD275. It inhibits the adhesion between T cells and endothelial cells, reduces the expansion of TR Treg cells, and is suitable for studies on inflammatory and infectious diseases such as influenza virus infection and arthritis.
Anti-Mouse ICOSL/CD275 Antibody (HK5.3)
Anti-Mouse ICOSL/CD275 Antibody (HK5.3)
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Purity: 95%
Catalog No. T9901A-1979
Anti-Mouse ICOSL/CD275 Antibody (HK5.3) is a monoclonal antibody against mouse ICOSL/CD275. It inhibits the adhesion between T cells and endothelial cells, reduces the expansion of TR Treg cells, and is suitable for studies on inflammatory and infectious diseases such as influenza virus infection and arthritis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $108 | 4-6 weeks | 4-6 weeks | |
| 5 mg | $388 | 4-6 weeks | 4-6 weeks | |
| 10 mg | Preferential | 4-6 weeks | 4-6 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95%
Appearance:Liquid
Color:Transparent
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| Description | Anti-Mouse ICOSL/CD275 Antibody (HK5.3) is a monoclonal antibody against mouse ICOSL/CD275. It inhibits the adhesion between T cells and endothelial cells, reduces the expansion of TR Treg cells, and is suitable for studies on inflammatory and infectious diseases such as influenza virus infection and arthritis. |
| In vitro | Anti-Mouse ICOSL/CD275 Antibody (HK5.3) (15 μg/mL, 30-minute treatment) significantly reduces the adhesion of Th1 and Th17 cells to primary mouse brain microvascular endothelial cells (pMBMECs) [2]. |
| In vivo | Anti-Mouse ICOSL/CD275 Antibody (HK5.3) (100 μg, intraperitoneal injection on days 0, 3, 6, and 9 after hydrodynamic tail vein injection) significantly reduces the clearance efficiency of senescent hepatocytes in wild-type C57BL/6 mice with a hepatocyte senescence model [1]. Anti-Mouse ICOSL/CD275 Antibody (HK5.3) (250–500 μg, intravenous injection on days -1, 1, and 3) markedly suppresses the expansion of TR Treg cells in C57BL/6 mice in an influenza virus infection model [3]. Intraperitoneal administration anti-Mouse ICOSL/CD275 Antibody (HK5.3) at 15 mg/kg (on days 19, 21, 23, and 25) significantly delays the onset of arthritis in female DBA/1 mice in a bovine collagen-induced arthritis model [4]. |
| Clone | HK5.3 |
| Reactivity | Mouse |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ICOSL/CD275 |
| Molecular Weight | 150 kDa |
| Isotype | Rat IgG2a kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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