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Sulfameter

Name: Sulfameter
Brand: TargetMol
SKU: T0748
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0748Cas No. 651-06-9

Alias Sulfametoxydiazine, 5-Methoxysulfadiazine

Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.

Sulfameter

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Purity: 99.90%

Catalog No. T0748Alias Sulfametoxydiazine, 5-MethoxysulfadiazineCas No. 651-06-9

Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.

Pack Size	Price	USA Warehouse	Global Warehouse
2 g	$32	-	In Stock
5 g	$52	-	In Stock
10 g	$81	Inquiry	Inquiry
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.90%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Sulfameter AI Summary

Sulfameter demonstrates a range of bioactivities with notable potencies across various assays. It is a potent inducer of genomic imprint erasure (3162.3 nM), DNA re-replication in MCF 10a breast cells (20.6 nM), and TGF-b activity inhibition (112.2 nM). Furthermore, it exhibits inhibitory effects against Lamin A splicing (12589.3 nM), AmpC Beta-Lactamase (354.8 nM), Hepatitis C Virus (35481.3 nM), Plasmodium falciparum proliferation (0.9 nM), PTHR (10000.0 nM), and Ebola virus entry (AC50 of 8912.5 nM). The compound has a log P value of 0.46 and an intrinsic solubility log 1/S0 value of 3.63. It also impacts sodium fluorescein uptake in OATP1B3 (112.86%) and OATP1B1 (233.46%) transfected CHO cells at 10 µM, indicating potential effects on transporter functions. Moderate liver toxicity is observed with choleostatic liver toxicity and a low percentage of acute liver toxicity noted in clinical trials, but without significant cytolytic, chronic, or severe liver toxicity indications. Against SARS-CoV-2, Sulfameter shows limited efficacy. It does not inhibit cell viability of infected Vero E6 cells and demonstrates varying levels of low antiviral activity in different assays. It inhibits SARS-CoV-2 3CL-Pro protease by 24.24% at 20 µM, but other assays reflect poor inhibition with IC50 values exceeding 20000.0 nM. In specific assays, it showed -1.71% and -0.16% inhibition of cytotoxicity in Caco-2 and Vero-6 cells, respectively, at 10 µM. Additionally, Sulfameter shows minor inhibitory activity on the human HDAC6 enzyme, with 11.53% inhibition in one assay and 0.35% in another..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.
Synonyms	Sulfametoxydiazine, 5-Methoxysulfadiazine

Chemical Properties

Molecular Weight	280.3
Formula	C₁₁H₁₂N₄O₃S
Cas No.	651-06-9
Smiles	S(NC=1N=CC(OC)=CN1)(=O)(=O)C2=CC=C(N)C=C2
Relative Density.	1.465 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 60 mg/mL (214.06 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.14 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5676 mL	17.8380 mL	35.6761 mL	178.3803 mL
5 mM	0.7135 mL	3.5676 mL	7.1352 mL	35.6761 mL
10 mM	0.3568 mL	1.7838 mL	3.5676 mL	17.8380 mL
20 mM	0.1784 mL	0.8919 mL	1.7838 mL	8.9190 mL
50 mM	0.0714 mL	0.3568 mL	0.7135 mL	3.5676 mL
100 mM	0.0357 mL	0.1784 mL	0.3568 mL	1.7838 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc