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Anti-STAT6 Antibody-PE (5D324)

🥰Excellent
Catalog No. TMAY-02527P

Anti-STAT6 Antibody-PE (5D324) is a PE-conjugated Mouse antibody targeting STAT6. Anti-STAT6 Antibody-PE (5D324) can be used in FCM.

Anti-STAT6 Antibody-PE (5D324)

Anti-STAT6 Antibody-PE (5D324)

🥰Excellent
Catalog No. TMAY-02527P
Anti-STAT6 Antibody-PE (5D324) is a PE-conjugated Mouse antibody targeting STAT6. Anti-STAT6 Antibody-PE (5D324) can be used in FCM.
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Product Introduction

Bioactivity
Description
Anti-STAT6 Antibody-PE (5D324) is a PE-conjugated Mouse antibody targeting STAT6. Anti-STAT6 Antibody-PE (5D324) can be used in FCM.
Ig Type
Monoclonal Mouse IgG1
Clone
5D324
Reactivity
Human
Verified Activity
Flow cytometric analysis of Human Stat6 expression in Jurkat cells. The cells were treated according to manufacturer’s manual (BD Pharmingen™ Cat. No. 554714), and then stained with PE Mouse anti-Human Stat6. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells.
Application
FCM
Recommended Dose
5 μl/Test, 0.1 mg/ml
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human STAT6 (rh STAT6; TMPY-02603; P42226-1; Met1-Trp847) and conjugated with PE under optimum conditions, the unreacted PE was removed.
PurificationProtein A
AppearanceLiquid
FormulationPBS solution containing 0.5% BSA and 0.09% sodium azide
Research BackgroundSignal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB.
Related Conjugates and Formulations
Conjucates
PE
Others Formats
Unconjugated/FITC
Antibody Types Available
3
Antigen Details
Immunogen
Recombinant Human STAT6 protein (TMPY-02603)
Antigen Species
Human
Biology Area
Apoptosis Transcription Factors and Regulators
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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