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Cletoquine

Name: Cletoquine
Brand: TargetMol
SKU: T10835
Price: 291 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T10835Cas No. 4298-15-1

Alias Desethylhydroxychloroquine

Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatment.

Cletoquine

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Purity: 99.98%

Catalog No. T10835Alias DesethylhydroxychloroquineCas No. 4298-15-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$291	-	In Stock
5 mg	$715	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,480	-	In Stock
50 mg	$1,980	-	In Stock
1 mL x 10 mM (in DMSO)	$688	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.98%

Color:White to Brown

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Cletoquine is a major active metabolite of Hydroxychloroquine. Cletoquine has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune disease treatment.
In vivo	Hydroxychloroquine is administered intravenously at a dosage of 5 mg/kg to BALB/c mice to assess the Cletoquine levels in blood and tissues. A tissue to blood concentration ratio (Kp) of ≥1 signifies Cletoquine's accumulation in tissues. The observed descending order of the Cletoquine Kp ratios across various tissues is liver (114.3), kidney (24.4), spleen (19.3), lungs (16.5), and heart (5.5).
Synonyms	Desethylhydroxychloroquine

Chemical Properties

Molecular Weight	307.82
Formula	C₁₆H₂₂ClN₃O
Cas No.	4298-15-1
Smiles	N(C(CCCNCCO)C)C=1C2=C(N=CC1)C=C(Cl)C=C2
Relative Density.	1.212 g/cm3

Storage & Solubility Information

Storage

keep away from moisture,store under nitrogen | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (178.68 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2487 mL	16.2433 mL	32.4865 mL	162.4326 mL
5 mM	0.6497 mL	3.2487 mL	6.4973 mL	32.4865 mL
10 mM	0.3249 mL	1.6243 mL	3.2487 mL	16.2433 mL
20 mM	0.1624 mL	0.8122 mL	1.6243 mL	8.1216 mL
50 mM	0.0650 mL	0.3249 mL	0.6497 mL	3.2487 mL
100 mM	0.0325 mL	0.1624 mL	0.3249 mL	1.6243 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc