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Anti-GMEB2 Polyclonal Antibody

Catalog No. TMAB-06598 Copy Product Info
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Anti-GMEB2 Polyclonal Antibody is a Rabbit antibody targeting GMEB2. Anti-GMEB2 Polyclonal Antibody can be used in WB.

Anti-GMEB2 Polyclonal Antibody

Copy Product Info
🥰Excellent
Catalog No. TMAB-06598

Anti-GMEB2 Polyclonal Antibody is a Rabbit antibody targeting GMEB2. Anti-GMEB2 Polyclonal Antibody can be used in WB.

Anti-GMEB2 Polyclonal Antibody
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2227-10 days7-10 days
100 μL$3747-10 days7-10 days
200 μL$5297-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-GMEB2 Polyclonal Antibody is a Rabbit antibody targeting GMEB2. Anti-GMEB2 Polyclonal Antibody can be used in WB.
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Chicken,Dog,Cow,Horse,Rabbit,Sheep)
Verified Activity
Sample: Bone (Mouse) Lysate at 40 μg
Primary: Anti-GMEB2 (TMAB-06598) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 56 kD
Observed band size: 56 kD
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus. Cytoplasm. May be also cytoplasmic.
Tissue SpecificityExpressed in peripheral blood lymphocytes and fetal liver. Expressed preferentially in reproductive and/or developmentally important cells, such as testis, placenta, bone marrow and fetal tissues.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundGMEB-2 is a DNA-binding protein that plays a crucial role modulating transcription upon activation by steroid hormones. GMEB-2 is ubiquitously expressed with preferential expression in developmentally important tissues, such as testis, bone marrow, placenta and fetal tissues. It localizes to the nucleus and cytoplasm and contains a SAND domain near its N-terminus and a C-terminal coiled coil structure. GMEB-2 functions as a homodimer or as a heterodimer with GMEB-1. The formed complex specifically binds to glucocorticoid modulatory elements (GME) in the promoter region of target genes and recruits the histone acetylase CREB binding protein (CBP) during glucocorticoid signaling. This acts to increase sensitivity to low concentrations of glucocorticoids. In addition, GMEB-2 functions as an auxiliary factor required for parvovirus replication.
Antigen Details
Immunogen
KLH conjugated synthetic peptide: human GMEB2
Antigen Species
Human
Gene Name
GMEB2
Gene ID
Protein Name
Glucocorticoid modulatory element-binding protein 2
Uniprot ID
Function
Trans-acting factor that binds to glucocorticoid modulatory elements (GME) present in the TAT (tyrosine aminotransferase) promoter and increases sensitivity to low concentrations of glucocorticoids. Binds also to the transferrin receptor promoter. Essential auxiliary factor for the replication of parvoviruses.
Chemical Properties
Molecular WeightTheoretical: 56 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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