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(+)-Sparteine
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Catalog No. T7853Cas No. 492-08-0
Alias Pachycarpine
(+)-Sparteine is a quinoline alkaloid extracted from Scotch broom, a sodium channel blocker and a class 1a antiarrhythmic agent. It competitively inhibits the activity of nicotinic acetylcholine receptors in nerve cells and is a ganglionic blocking agent.
(+)-Sparteine
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Purity: 99.98%
Catalog No. T7853Alias PachycarpineCas No. 492-08-0
(+)-Sparteine is a quinoline alkaloid extracted from Scotch broom, a sodium channel blocker and a class 1a antiarrhythmic agent. It competitively inhibits the activity of nicotinic acetylcholine receptors in nerve cells and is a ganglionic blocking agent.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 200 mg | $30 | In Stock | In Stock | |
| 500 mg | $44 | In Stock | In Stock | |
| 1 g | $73 | - | In Stock | |
| 5 g | $185 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.98%
Appearance:Liquid
Color:Transparent to Yellow
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | (+)-Sparteine is a quinoline alkaloid extracted from Scotch broom, a sodium channel blocker and a class 1a antiarrhythmic agent. It competitively inhibits the activity of nicotinic acetylcholine receptors in nerve cells and is a ganglionic blocking agent. |
| In vitro | (+)-Sparteine (Pachycarpine) (2 μM) reduces ACh-induced currents caused by activation of nicotinic ACh receptors (AChRs) in a voltage-independent manner at membrane potentials between -50 mV and +30 mV; the ACh dose-response relationship is altered by 2 μM (+)-Sparteine (Pachycarpine) at -50 mV and -90 mV in a manner typical of a competitive but not competitive antagonist. [1] |
| Synonyms | Pachycarpine |
| Molecular Weight | 234.38 |
| Formula | C15H26N2 |
| Cas No. | 492-08-0 |
| Smiles | [C@]12([C@@]3(N(C[C@@](C1)([C@]4(N(C2)CCCC4)[H])[H])CCCC3)[H])[H] |
| Relative Density. | 1.08g/cm3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (21.33 mM), Sonication is recommended.  H2O: 2.86 mg/mL (12.2 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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