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(+)-Sparteine
🥰Excellent
Catalog No. T7853Cas No. 492-08-0
Alias Pachycarpine
(+)-Sparteine is a quinoline alkaloid extracted from Scotch broom, a sodium channel blocker and a class 1a antiarrhythmic agent. It competitively inhibits the activity of nicotinic acetylcholine receptors in nerve cells and is a ganglionic blocking agent.
(+)-Sparteine
🥰Excellent
Purity: 99.9%
Catalog No. T7853Alias PachycarpineCas No. 492-08-0
(+)-Sparteine is a quinoline alkaloid extracted from Scotch broom, a sodium channel blocker and a class 1a antiarrhythmic agent. It competitively inhibits the activity of nicotinic acetylcholine receptors in nerve cells and is a ganglionic blocking agent.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 200 mg | $30 | In Stock | |
| 500 mg | $44 | In Stock | |
| 1 g | $73 | In Stock | |
| 5 g | $185 | In Stock |
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Purity:99.9%
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Product Introduction
Bioactivity
Chemical Properties
| Description | (+)-Sparteine is a quinoline alkaloid extracted from Scotch broom, a sodium channel blocker and a class 1a antiarrhythmic agent. It competitively inhibits the activity of nicotinic acetylcholine receptors in nerve cells and is a ganglionic blocking agent. |
| In vitro | (+)-Sparteine (Pachycarpine) (2 μM) reduces ACh-induced currents caused by activation of nicotinic ACh receptors (AChRs) in a voltage-independent manner at membrane potentials between -50 mV and +30 mV; the ACh dose-response relationship is altered by 2 μM (+)-Sparteine (Pachycarpine) at -50 mV and -90 mV in a manner typical of a competitive but not competitive antagonist. [1] |
| Synonyms | Pachycarpine |
| Molecular Weight | 234.38 |
| Formula | C15H26N2 |
| Cas No. | 492-08-0 |
| Smiles | [C@]12([C@@]3(N(C[C@@](C1)([C@]4(N(C2)CCCC4)[H])[H])CCCC3)[H])[H] |
| Relative Density. | 1.08g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 5 mg/mL (21.3 mM), Sonication is recommended.  H2O: 2.86 mg/mL (12.20 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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