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Diosmin

Name: Diosmin
Brand: TargetMol
SKU: T0878
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0878Cas No. 520-27-4

Alias Venosmine, Diosmil, Barosmin

Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.

Diosmin

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Purity: 97.90%

Catalog No. T0878Alias Venosmine, Diosmil, BarosminCas No. 520-27-4

Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$33	In Stock	In Stock
50 mg	$45	In Stock	In Stock
100 mg	$72	In Stock	In Stock
500 mg	$169	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.90%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

Diosmin AI Summary

Diosmin exhibits a broad spectrum of bioactivities. It shows antioxidant activity in BALB/c mouse bone marrow cells by inhibiting ROS production (IC25: 70.0 nM) and demonstrates no inhibition on cow milk xanthine oxidase at 50 µg/mL. The compound is stable in Hank's balanced salt solution at 15 µM but drops to 0% stability after 24 hours and has moderate permeability in human Caco-2 cells. It inhibits TNFalpha expression in LPS-stimulated human monocytes (IC50 > 200,000.0 nM). In terms of biochemical interactions, Diosmin inhibits multiple targets, including the MLL CXXC domain-DNA interaction, Menin-MLL interaction, AmpC Beta-Lactamase, DNA Polymerase Beta, JMJD2A-Tudor Domain, GCN5L2, and various others. It shows antihyperlipidemic and antidiabetic activities in mouse models, reducing serum cholesterol, triglycerides, and blood glucose levels. It also inhibits PTP1B activity and F1F0-ATP synthase in E. coli. For viral activities, Diosmin marginally inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 and Caco-2 cells while showing weak activity against SARS-CoV-2 in HRCE cells. It inhibits LSD1 and human HDAC6, albeit with low potency. It also demonstrates cytotoxicity against mouse C2C12 cells (IC10: 5.14 µg/mL, IC50: 19.97 µg/mL). Diosmin has a log P value of -0.1, indicating low lipophilicity, and an aqueous solubility of 1.2 µg/mL. It inhibits OATP1B3 and OATP1B1 uptake of sodium fluorescein. The compound also shows bioactivity in modulating the NorA efflux pump in Staphylococcus aureus and exhibits antioxidant and antiproliferative activities against several cancer cell lines. Despite this, it shows no significant activity against a range of receptor targets and enzymes in vitro, with an AC50 > 30,000.0 nM, indicating limited efficacy in receptor binding and enzyme inhibition..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Diosmin (Venosmine) is a bioflavonoid that strengthens vascular walls.
Synonyms	Venosmine, Diosmil, Barosmin

Chemical Properties

Molecular Weight	608.54
Formula	C₂₈H₃₂O₁₅
Cas No.	520-27-4
Smiles	O=C1C=2C(OC(=C1)C3=CC(O)=C(OC)C=C3)=CC(O[C@@H]4O[C@H](CO[C@H]5[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5)[C@@H](O)[C@H](O)[C@H]4O)=CC2O
Relative Density.	1.68 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 100 mg/mL (164.33 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6433 mL	8.2164 mL	16.4328 mL	82.1639 mL
5 mM	0.3287 mL	1.6433 mL	3.2866 mL	16.4328 mL
10 mM	0.1643 mL	0.8216 mL	1.6433 mL	8.2164 mL
20 mM	0.0822 mL	0.4108 mL	0.8216 mL	4.1082 mL
50 mM	0.0329 mL	0.1643 mL	0.3287 mL	1.6433 mL
100 mM	0.0164 mL	0.0822 mL	0.1643 mL	0.8216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc