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8-Hydroxyquinoline

Name: 8-Hydroxyquinoline
Brand: TargetMol
SKU: T0404
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0404Cas No. 148-24-3

Alias Oxine, Hydroxyquinoline, 8-Quinolinol, 8-Oxychinolin

8-Hydroxyquinoline (8-Quinolinol) is a heterocyclic phenol derived from quinoline, possessing antiseptic, disinfectant, and pesticide properties. It serves as a stabilizer for hydrogen peroxide and is occasionally added to cosmetic products.

8-Hydroxyquinoline

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Purity: 99.23%

Catalog No. T0404Alias Oxine, Hydroxyquinoline, 8-Quinolinol, 8-OxychinolinCas No. 148-24-3

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$31	In Stock	In Stock
1 g	$38	In Stock	In Stock
5 g	$48	-	In Stock
10 g	$68	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.23%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HNMR

Product Introduction

8-Hydroxyquinoline AI Summary

8-Hydroxyquinoline inhibits the growth of various cancer cell lines, such as KB and FM3A cells, with IC50 values under 2100 nM, and shows antitumor effects in mice with P388 leukemia. It exhibits significant antimycobacterial and antifungal activities, including inhibition of Mycobacterium tuberculosis and Candida species. The compound displays a broad range of bioactivities, including chelation with metal ions, antioxidant properties, enzyme inhibition, and cytotoxicity against cancer cells. It shows inhibitory effects on enzymes like matrix metalloproteinases (MMPs), methionine aminopeptidases (MetAPs), and human recombinant IDO. Additionally, it demonstrates antibacterial activity against diverse pathogens and has antiviral potential against SARS-CoV-2. Despite its diverse bioactivities, it displays moderate lipophilicity and selectivity in its inhibitory actions. 8-Hydroxyquinoline also exhibits modest inhibitory activity against enzymes like HDAC6 and QC, and it affects liver, kidney, and blood parameters in various assays..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	8-Hydroxyquinoline (8-Quinolinol) is a heterocyclic phenol derived from quinoline, possessing antiseptic, disinfectant, and pesticide properties. It serves as a stabilizer for hydrogen peroxide and is occasionally added to cosmetic products.
Synonyms	Oxine, Hydroxyquinoline, 8-Quinolinol, 8-Oxychinolin

Chemical Properties

Molecular Weight	145.16
Formula	C₉H₇NO
Cas No.	148-24-3
Smiles	OC1=CC=CC2=CC=CN=C12
Relative Density.	1.034 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (344.45 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (13.78 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.8890 mL	34.4448 mL	68.8895 mL	344.4475 mL
5 mM	1.3778 mL	6.8890 mL	13.7779 mL	68.8895 mL
10 mM	0.6889 mL	3.4445 mL	6.8890 mL	34.4448 mL
20 mM	0.3444 mL	1.7222 mL	3.4445 mL	17.2224 mL
50 mM	0.1378 mL	0.6889 mL	1.3778 mL	6.8890 mL
100 mM	0.0689 mL	0.3444 mL	0.6889 mL	3.4445 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc