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Zoxazolamine

Name: Zoxazolamine
Brand: TargetMol
SKU: T0922
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0922Cas No. 61-80-3

Alias NSC 24995, Contrazole

Zoxazolamine (NSC-24995) is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.

Zoxazolamine

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Purity: 99.54%

Catalog No. T0922Alias NSC 24995, ContrazoleCas No. 61-80-3

Zoxazolamine (NSC-24995) is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
200 mg	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.54%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Zoxazolamine (NSC-24995) is a uricosuric and muscle relaxant. Zoxazolamine acts centrally as a muscle relaxant, but the mechanism of its action is not understood.
In vivo	Zoxazolamine, a biologically active 2-amino-2-oxazole compound, functions as a central muscle relaxant by diminishing the activity between central neurons. It is not an anxiolytic; instead, it reduces dopaminergic turnover and induces a pacemaker-like discharge pattern in dopaminergic neurons. Zoxazolamine is also utilized in assessing hepatic cytochrome P-450 activity.
Synonyms	NSC 24995, Contrazole

Chemical Properties

Molecular Weight	168.58
Formula	C₇H₅ClN₂O
Cas No.	61-80-3
Smiles	NC1=NC2=CC(Cl)=CC=C2O1
Relative Density.	1.4369 g/cm3 (Estimated)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 32 mg/mL (189.82 mM), Sonication is recommended.

Ethanol: 32 mg/mL (189.82 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (11.86 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	5.9319 mL	29.6595 mL	59.3190 mL	296.5951 mL
5 mM	1.1864 mL	5.9319 mL	11.8638 mL	59.3190 mL
10 mM	0.5932 mL	2.9660 mL	5.9319 mL	29.6595 mL
20 mM	0.2966 mL	1.4830 mL	2.9660 mL	14.8298 mL
50 mM	0.1186 mL	0.5932 mL	1.1864 mL	5.9319 mL
100 mM	0.0593 mL	0.2966 mL	0.5932 mL	2.9660 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc