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Raspberry ketone

Name: Raspberry ketone
Brand: TargetMol
SKU: T2S0633
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2S0633Cas No. 5471-51-2

Alias Rasketone, p-Hydroxybenzyl acetone, Oxyphenalon, Frambinone, Aloenin, 4-(4-Hydroxyphenyl)-2-butanone

1. Raspberry ketone (p-Hydroxybenzyl acetone) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can cause chemical/occupational leukoderma. 2. Raspberry ketone is marketed on the Internet as a food supplement.

Raspberry ketone

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Purity: 99.89%

Catalog No. T2S0633Alias Rasketone, p-Hydroxybenzyl acetone, Oxyphenalon, Frambinone, Aloenin, 4-(4-Hydroxyphenyl)-2-butanoneCas No. 5471-51-2

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.89%

Appearance:Solid

Color:White

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Raspberry ketone AI Summary

Raspberry ketone exhibits in vitro cell growth inhibitory activity against the K562 human chronic myelogenous leukemia cell line, with an IC50 value greater than 100,000.0 nM. It also demonstrates antagonist activity at the androgen receptor (AR) in human MDA-kb2 cells co-transfected with MMTV-luciferase, resulting in a decrease in dihydrotestosterone (DHT)-induced luciferase activity, with IC50 values of 252,000.0 nM and 251,188.64 nM. Additionally, Raspberry ketone shows drug uptake in Wistar rat blood at a dose of 10 g/kg, with a recorded value of 4000.0 ng/ml. The compound induces the production of nerve growth factor (NGF) in rat C6 cells at 20 µM after 24 hours, with an activity of 106.8% compared to the untreated control, as measured by ELISA. Furthermore, it exhibits cytotoxicity against rat C6 cells at the same concentration and time point, with an activity of 100.9% as measured by the MTT assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Raspberry ketone (p-Hydroxybenzyl acetone) is cytotoxic to melanocytes through the binding of RK-derived quinones to thiol proteins and the pro-oxidant activity of the RK-oligomer, the exposure of human skin to RK can cause chemical/occupational leukoderma. 2. Raspberry ketone is marketed on the Internet as a food supplement.
Synonyms	Rasketone, p-Hydroxybenzyl acetone, Oxyphenalon, Frambinone, Aloenin, 4-(4-Hydroxyphenyl)-2-butanone

Chemical Properties

Molecular Weight	164.2
Formula	C₁₀H₁₂O₂
Cas No.	5471-51-2
Smiles	C(CC(C)=O)C1=CC=C(O)C=C1
Relative Density.	1.167 g/cm3. Temperature:20 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (365.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (12.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	6.0901 mL	30.4507 mL	60.9013 mL	304.5067 mL
5 mM	1.2180 mL	6.0901 mL	12.1803 mL	60.9013 mL
10 mM	0.6090 mL	3.0451 mL	6.0901 mL	30.4507 mL
20 mM	0.3045 mL	1.5225 mL	3.0451 mL	15.2253 mL
50 mM	0.1218 mL	0.6090 mL	1.2180 mL	6.0901 mL
100 mM	0.0609 mL	0.3045 mL	0.6090 mL	3.0451 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc