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Anti-Cathepsin Z Antibody (3J329)
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Catalog No. TMAY-03094
Alias CTSX, cathepsin Z
Anti-Cathepsin Z Antibody (3J329) is a Rabbit antibody targeting Cathepsin Z. Anti-Cathepsin Z Antibody (3J329) can be used in ELISA,ICC/IF.
Anti-Cathepsin Z Antibody (3J329)
Anti-Cathepsin Z Antibody (3J329)
😃Good
Catalog No. TMAY-03094Alias CTSX, cathepsin Z
Anti-Cathepsin Z Antibody (3J329) is a Rabbit antibody targeting Cathepsin Z. Anti-Cathepsin Z Antibody (3J329) can be used in ELISA,ICC/IF.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Chemical Properties
| Description | Anti-Cathepsin Z Antibody (3J329) is a Rabbit antibody targeting Cathepsin Z. Anti-Cathepsin Z Antibody (3J329) can be used in ELISA,ICC/IF. |
| Alias | CTSX, cathepsin Z |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 3J329 |
| Reactivity | Mouse |
| Verified Activity | Immunofluorescence staining of mCTSZ in RAW264.7 cells. Cells were fixed with 4% PFA,blocked with 10% serum, and incubated with rabbit anti-Mouse mCTSZ monoclonal antibody (dilution ratio 1:60) at 4°C overnight. Then cells were stained with the Alexa Fluor®488-conjugated Goat Anti-rabbit IgG secondary antibody (green). Positive staining was localized to Cytoplasm. |
| Application | ELISA,ICC/IF |
| Recommended Dose | ELISA: 1:5000-1:10000; ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CTSZ / CTSX / Cathepsin Z (rM CTSZ / CTSX / Cathepsin Z; TMPY-00736; NP_071720.1; Met 1-Val 306). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Cathepsin Z (CTSZ), also known as Cathepsin X or CATX, belongs to the C1 family of lysosomal cysteine proteases. Its gene structure and activity properties show several unique features that distinguish it clearly from other human cysteine proteases. It has a very short pro-region that shows no similarity to those of other cathepsins and a three-residue insertion motif that forms a characteristic ‘mini loop’. Cathepsin Z exhibits mono- and di-peptidase activity at its C-terminus, and in contrast to cathepsin B, it does not act as an endopeptidase. It is restricted to the cells of theimmune system, predominantly monocytes, macrophages and dendritic cells. Cathepsin Z is widely expressed in human tissues, suggesting that this enzyme could be involved in the normal intracellular protein degradation taking place in all cell types. It is capable to cleave regulatory motifs at C-terminus affecting the function of targeted molecules. Cathepsin X may regulate also the maturation of dendritic cells, a process, which is crucial in the initiation of adaptive immunity. Furthermore, higher levels of Cathepsin Z are also found in tumour and immune cells of prostate and gastric carcinomas and inmacrophages of gastric mucosa, especially after infection by Helicobacter pylori. Cathepsin Z is also ubiquitously distributed in cancer cell lines and in primary tumors from different sources, suggesting that this enzyme may participate in tumor progression. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Mouse CTSZ / CTSX / Cathepsin Z protein (TMPY-00736) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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