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ent-Ezetimibe

Name: ent-Ezetimibe
Brand: TargetMol
SKU: T11205
Price: 107 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T11205Cas No. 1376614-99-1

Alias ent-SCH 58235

Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.ent-Ezetimibe (ent-SCH 58235) (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor.

ent-Ezetimibe

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Purity: 99.57%

Catalog No. T11205Alias ent-SCH 58235Cas No. 1376614-99-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$107	In Stock	In Stock
5 mg	$228	In Stock	In Stock
10 mg	$338	In Stock	In Stock
25 mg	$532	In Stock	In Stock
50 mg	$738	In Stock	In Stock
100 mg	$980	In Stock	In Stock
200 mg	$1,350	-	In Stock
1 mL x 10 mM (in DMSO)	$258	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.57%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Ezetimibe is a Niemann-Pick C1-like1 (NPC1L1) inhibitor, and is a potent Nrf2 activator.ent-Ezetimibe (ent-SCH 58235) (ent-SCH 58235) is the RRS-enantiomer of Ezetimibe. Ezetimibe is a potent cholesterol absorption inhibitor.
Synonyms	ent-SCH 58235

Chemical Properties

Molecular Weight	409.43
Formula	C₂₄H₂₁F₂NO₃
Cas No.	1376614-99-1
Smiles	C(C[C@@H](O)C1=CC=C(F)C=C1)[C@H]2[C@@H](N(C2=O)C3=CC=C(F)C=C3)C4=CC=C(O)C=C4
Relative Density.	1.334 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (146.55 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4424 mL	12.2121 mL	24.4242 mL	122.1210 mL
5 mM	0.4885 mL	2.4424 mL	4.8848 mL	24.4242 mL
10 mM	0.2442 mL	1.2212 mL	2.4424 mL	12.2121 mL
20 mM	0.1221 mL	0.6106 mL	1.2212 mL	6.1060 mL
50 mM	0.0488 mL	0.2442 mL	0.4885 mL	2.4424 mL
100 mM	0.0244 mL	0.1221 mL	0.2442 mL	1.2212 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc