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SRPIN340

Name: SRPIN340
Brand: TargetMol
SKU: T1954
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1954Cas No. 218156-96-8

Alias SRPK inhibitor

SRPIN340 (SRPK inhibitor), a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).

SRPIN340

🥰Excellent

Purity: 99.96%

Catalog No. T1954Alias SRPK inhibitorCas No. 218156-96-8

SRPIN340 (SRPK inhibitor), a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$39	In Stock	In Stock
5 mg	$63	In Stock	In Stock
10 mg	$107	In Stock	In Stock
25 mg	$197	In Stock	In Stock
50 mg	$360	In Stock	In Stock
100 mg	$468	In Stock	In Stock
500 mg	$1,050	-	In Stock
1 mL x 10 mM (in DMSO)	$68	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.96%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	SRPIN340 (SRPK inhibitor), a serine/arginine-rich protein kinase (SRPK)-specific inhibitor, is potent for SRPK1 (IC50 = 0.89 uM).
Targets&IC50	SRPK1:0.89 μM(Ki)
In vitro	In Flp-In293 cells, SRPIN340 inhibited SR phosphorylation via SRPK, promoted SRp75 degradation, and subsequently inhibited the production of HIV.In CHO cells, SRPIN340 (5 mg/ml) did not produce abnormalities in chromosome structure and chromosome number.
In vivo	In Flp-In293 cells, SRPIN340 inhibited SR phosphorylation via SRPK, promoted SRp75 degradation, and subsequently inhibited the production of HIV.In CHO cells, SRPIN340 (5 mg/ml) did not produce abnormalities in chromosome structure and chromosome number.
Synonyms	SRPK inhibitor

Chemical Properties

Molecular Weight	349.35
Formula	C₁₈H₁₈F₃N₃O
Cas No.	218156-96-8
Smiles	FC(F)(F)c1ccc(N2CCCCC2)c(NC(=O)c2ccncc2)c1
Relative Density.	1.306 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 65 mg/mL (186.06 mM), Sonication is recommended.

DMSO: 60 mg/mL (171.75 mM), Sonication is recommended.

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	2.8625 mL	14.3123 mL	28.6246 mL	143.1229 mL
5 mM	0.5725 mL	2.8625 mL	5.7249 mL	28.6246 mL
10 mM	0.2862 mL	1.4312 mL	2.8625 mL	14.3123 mL
20 mM	0.1431 mL	0.7156 mL	1.4312 mL	7.1561 mL
50 mM	0.0572 mL	0.2862 mL	0.5725 mL	2.8625 mL
100 mM	0.0286 mL	0.1431 mL	0.2862 mL	1.4312 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc