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Sclareol

Name: Sclareol
Brand: TargetMol
SKU: T3020
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3020Cas No. 515-03-7

Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.

Sclareol

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Purity: 99.97%

Catalog No. T3020Cas No. 515-03-7

Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$38	In Stock	In Stock
50 mg	$53	In Stock	In Stock
100 mg	$74	In Stock	In Stock
500 mg	$173	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.97%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sclareol, a labdane-type diterpene isolated from clary sage (Salvia sclarea), exerts growth inhibition and cytotoxic activity against a variety of human Y cell lines.
In vitro	Ingestion of Sclareol in rats demonstrates an LD50 greater than 5 g/kg.
In vivo	Sclareol inhibits DNA synthesis in human breast cancer cell lines, inducing apoptosis that does not depend on p53 and causing cell cycle arrest at the G(0/1) phase. Intratumoral injection of Sclareol decreases in-vivo growth of breast cancer tumors. It demonstrates growth inhibition and cytotoxicity across various human cancer cell lines. Additionally, Sclareol exhibits anti-inflammatory activity in lipopolysaccharide-stimulated macrophages by reducing the expression of inflammatory cytokines and increasing the activity of antioxidant enzymes.

Chemical Properties

Molecular Weight	308.5
Formula	C₂₀H₃₆O₂
Cas No.	515-03-7
Smiles	C[C@]12[C@@](CC[C@@](C)(O)[C@@H]1CC[C@@](C=C)(C)O)(C(C)(C)CCC2)[H]
Relative Density.	0.954 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 250 mg/mL (810.37 mM), Sonication is recommended.

Ethanol: 23 mg/mL (74.55 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (16.21 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2415 mL	16.2075 mL	32.4149 mL	162.0746 mL
5 mM	0.6483 mL	3.2415 mL	6.4830 mL	32.4149 mL
10 mM	0.3241 mL	1.6207 mL	3.2415 mL	16.2075 mL
20 mM	0.1621 mL	0.8104 mL	1.6207 mL	8.1037 mL
50 mM	0.0648 mL	0.3241 mL	0.6483 mL	3.2415 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0324 mL	0.1621 mL	0.3241 mL	1.6207 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc