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PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $215 | In Stock | |
5 mg | $538 | In Stock | |
10 mg | $868 | In Stock | |
25 mg | $1,730 | In Stock | |
50 mg | $2,820 | In Stock | |
100 mg | $4,520 | In Stock |
Description | PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity. |
Targets&IC50 | HCC1954 cells:0.37 μM, RMUG-S cells:8 nM |
In vitro | PARG-IN-4 shows strong anti-proliferative effects against ovarian and breast cancer cells. It inhibited cell growth with IC₅₀ values ranging from 8 nM (RMUG-S) to 0.37 μM (HCC1954), depending on the cell line[1]. |
In vivo | In a patient-derived xenograft (PDX) mouse model (HBCx-34), oral administration of PARG-IN-4 (100 mg/kg, once daily for 45 days) led to complete tumor regression, achieving a tumor growth inhibition rate (TGI) of 110%[1]. |
Molecular Weight | 497.59 |
Formula | C20H25F2N7O2S2 |
Cas No. | 2988890-20-4 |
Smiles | S(NC1(C)CC1)(=O)(=O)C=2C=C3C(=C(C2)N4C[C@H](C)N[C@@H](C)C4)C=NN3C=5SC(C(F)F)=NN5 |
Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
Solubility Information | DMSO: 16 mg/mL (32.15 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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