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PARG-IN-4

🥰Excellent
Catalog No. T81546Cas No. 2988890-20-4

PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity.

PARG-IN-4

PARG-IN-4

🥰Excellent
Purity: 98.51%
Catalog No. T81546Cas No. 2988890-20-4
PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity.
Pack SizePriceAvailabilityQuantity
1 mg$215In Stock
5 mg$538In Stock
10 mg$868In Stock
25 mg$1,730In Stock
50 mg$2,820In Stock
100 mg$4,520In Stock
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Purity:98.51%
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Product Introduction

Bioactivity
Description
PARG-IN-4 (compound A) is an orally active and cell-membrane permeable PARG inhibitor (EC50=1.9 nM) that inhibits tumour growth in mice with antitumour activity.
Targets&IC50
HCC1954 cells:0.37 μM, RMUG-S cells:8 nM
In vitro
PARG-IN-4 shows strong anti-proliferative effects against ovarian and breast cancer cells. It inhibited cell growth with IC₅₀ values ranging from 8 nM (RMUG-S) to 0.37 μM (HCC1954), depending on the cell line[1].
In vivo
In a patient-derived xenograft (PDX) mouse model (HBCx-34), oral administration of PARG-IN-4 (100 mg/kg, once daily for 45 days) led to complete tumor regression, achieving a tumor growth inhibition rate (TGI) of 110%[1].
Chemical Properties
Molecular Weight497.59
FormulaC20H25F2N7O2S2
Cas No.2988890-20-4
SmilesS(NC1(C)CC1)(=O)(=O)C=2C=C3C(=C(C2)N4C[C@H](C)N[C@@H](C)C4)C=NN3C=5SC(C(F)F)=NN5
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 16 mg/mL (32.15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0097 mL10.0484 mL20.0969 mL100.4843 mL
5 mM0.4019 mL2.0097 mL4.0194 mL20.0969 mL
10 mM0.2010 mL1.0048 mL2.0097 mL10.0484 mL
20 mM0.1005 mL0.5024 mL1.0048 mL5.0242 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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