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2'-Deoxy-2'-fluorocytidine

Name: 2'-Deoxy-2'-fluorocytidine
Brand: TargetMol
SKU: T38238
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T38238Cas No. 10212-20-1

2'-Deoxy-2'-fluorocytidine, a nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication and can act synergistically with T705 to enhance the antiviral effects on CCHFV replication[1]. It exhibits antiviral activity with EC50 values of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively, and has a CC50 of >50.0 μM in Huh7 cells[1].

[1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.

2'-Deoxy-2'-fluorocytidine

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Purity: 99.90%

Catalog No. T38238Cas No. 10212-20-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
100 mg	$29	In Stock	-
500 mg	$59	Inquiry	Inquiry

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.90%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	2'-Deoxy-2'-fluorocytidine, a nucleoside analog, is a potent inhibitor of Crimean-Congo hemorrhagic fever virus (CCHFV) replication and can act synergistically with T705 to enhance the antiviral effects on CCHFV replication[1]. It exhibits antiviral activity with EC50 values of 61 nM and 31 nM against CCHFV and CCHFV/ZsG in Huh7 cells, respectively, and has a CC50 of >50.0 μM in Huh7 cells[1]. [1]. Stephen R Welch, et al. Identification of 2'-deoxy-2'-fluorocytidine as a potent inhibitor of Crimean-Congo hemorrhagic fever virus replication using a recombinant fluorescent reporter virus. Antiviral Res. 2017 Nov;147:91-99.
Targets&IC50	CCFHV:61 ± 18 nM(EC50)
In vitro	2'-Deoxy-2'-fluorocytidine exhibits antiviral activity with 50% effective concentrations (EC50) of 61 nM against CCHFV and 31 nM against CCHFV/ZsG in Huh7 cells and shows a 50% cytotoxicity concentration (CC50) of >50.0 μM in Huh7 cells[1].

Chemical Properties

Molecular Weight	245.21
Formula	C₉H₁₂FN₃O₄
Cas No.	10212-20-1
Smiles	Nc1ccn([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2F)c(=O)n1
Relative Density.	1.82 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (203.91 mM), Sonication is recommended.

H2O: 5 mg/mL (20.39 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0781 mL	20.3907 mL	40.7814 mL	203.9069 mL
5 mM	0.8156 mL	4.0781 mL	8.1563 mL	40.7814 mL
10 mM	0.4078 mL	2.0391 mL	4.0781 mL	20.3907 mL
20 mM	0.2039 mL	1.0195 mL	2.0391 mL	10.1953 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0816 mL	0.4078 mL	0.8156 mL	4.0781 mL
100 mM	0.0408 mL	0.2039 mL	0.4078 mL	2.0391 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc