Shopping Cart
- Remove All
Your shopping cart is currently empty
Anti-Fas/CD95 Antibody-PE (2C992)
🥰Excellent
Catalog No. TMAY-03725P
Anti-Fas/CD95 Antibody-PE (2C992) is a PE-conjugated Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody-PE (2C992) can be used in FCM.
Anti-Fas/CD95 Antibody-PE (2C992)
Anti-Fas/CD95 Antibody-PE (2C992)
🥰Excellent
Catalog No. TMAY-03725P
Anti-Fas/CD95 Antibody-PE (2C992) is a PE-conjugated Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody-PE (2C992) can be used in FCM.
Product information is being updated, if you want to purchase, please click the bulk custom button.
Bulk & Custom
Questions
View MoreContact us for more batch information
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Fas/CD95 Antibody-PE (2C992) is a PE-conjugated Rabbit antibody targeting Fas/CD95. Anti-Fas/CD95 Antibody-PE (2C992) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 2C992 |
| Reactivity | Rat |
| Verified Activity | Flow cytometric analysis of Rat FAS(CD95) expression on SD rat splenocytes. Cells were stained with PE-conjugated anti-Rat FAS(CD95). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Rat CD95 / APO-1 / TNFRSF6 (rR CD95 / APO-1 / TNFRSF6; TMPY-02057; NP_631933.2; Met1-Lys170) and conjugated with PE under optimum conditions, the unreacted PE was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | CD95 (APO-1/Fas) is an important inducer of the extrinsic apoptosis signaling pathway and therapy induced apoptosis of many tumor cells has been linked to the activity of CD95. is a prototype death receptor characterized by the presence of an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the recruitment of a number of signaling components upon activation by either agonistic anti-CD95 antibodies or cognate CD95 ligand that initiate apoptosis. The complex of proteins that forms upon triggering of CD95 is called the death-inducting signaling complex (DISC). The DISC consists of an adaptor protein and initiator caspases and is essential for induction of apoptosis. CD95 is also crucial for the negative selection of B cells within the germinal center (GC). Impairment of CD95-mediated apoptosis results in defective affinity maturation and the persistence of autoreactive B-cell clones. Changes in the expression of CD95 and/or its ligand CD95L are frequently found in human cancer. The downregulation or mutation of CD95 has been proposed as a mechanism by which cancer cells avoid destruction by the immune system through reduced apoptosis sensitivity. Thus, CD95 has therefore been viewed as a tumor suppressor. CD95 has been reported to be involved in the activation of NF-kappaB, MAPK3/ERK1, MAPK8/JNK, and the alternate pathways for CTL-mediated cytotoxicity. Accordingly, this protein is implicated in the pathogenesis of various malignancies and diseases of the immune system. The CD95/CD95L system was implicated in the etiology of inflammatory bowel disease (IBD) based, primarily, on the finding that CD95 is highly expressed in the intestinal epithelial cells and that epithelial apoptosis is increased in IBD. |
| Conjucates | PE |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Rat CD95 / APO-1 / TNFRSF6 protein (TMPY-02057) |
| Antigen Species | Rat |
| Biology Area | Tumor Suppressors |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
Sci Citations
Calculator
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Anti-Fas/CD95 Antibody-PE (2C992) | purchase Anti-Fas/CD95 Antibody-PE (2C992) | Anti-Fas/CD95 Antibody-PE (2C992) cost | order Anti-Fas/CD95 Antibody-PE (2C992)
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.