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Alisol B 23-acetate

Name: Alisol B 23-acetate
Brand: TargetMol
SKU: T6S2246
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6S2246Cas No. 26575-95-1

Alias Alisol B monoacetate, Alisol B Acetate, 23-O-Acetylalisol B, 23-Acetylalismol B

1. Alisol B 23-acetate (Alisol B Acetate) produces protective effect against ANIT-induced hepatotoxity and cholestasis, due to FXR-mediated regulation of transporters and enzymes. 2. Alisol B 23-acetate produces promotive effect on liver regeneration, due to FXR-mediated regulation of genes involved in hepatocyte proliferation and hepato-protection. 3. Alisol B 23-acetate produces a protective effect against CCl4-induced hepatotoxicity, due to FXR and STAT3-mediated gene regulation.

Alisol B 23-acetate

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Purity: 99.95%

Catalog No. T6S2246Alias Alisol B monoacetate, Alisol B Acetate, 23-O-Acetylalisol B, 23-Acetylalismol BCas No. 26575-95-1

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$39	In Stock	In Stock
10 mg	$59	In Stock	In Stock
25 mg	$122	In Stock	In Stock
50 mg	$179	In Stock	In Stock
100 mg	$266	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$44	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.95%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Alisol B 23-acetate AI Summary

Alisol B 23-acetate exhibits bioactivity related to the transactivation of the Farnesoid X Receptor (FXR) in HepG2 cells expressing pBSEP/pGL4.74. This was demonstrated through a luciferase reporter gene assay, revealing an EC50 value of 3570.0 nM, which indicates the compound's potency in modulating FXR transactivation..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Alisol B monoacetate, Alisol B Acetate, 23-O-Acetylalisol B, 23-Acetylalismol B

Chemical Properties

Molecular Weight	514.74
Formula	C₃₂H₅₀O₅
Cas No.	26575-95-1
Smiles	C[C@H](C[C@H](OC(C)=O)[C@H]1OC1(C)C)C1=C2C[C@H](O)[C@H]3[C@@]4(C)CCC(=O)C(C)(C)[C@@H]4CC[C@]3(C)[C@@]2(C)CC1
Relative Density.	1.12 g/cm3

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight,store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 125 mg/mL (242.84 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.89 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9427 mL	9.7136 mL	19.4273 mL	97.1364 mL
5 mM	0.3885 mL	1.9427 mL	3.8855 mL	19.4273 mL
10 mM	0.1943 mL	0.9714 mL	1.9427 mL	9.7136 mL
20 mM	0.0971 mL	0.4857 mL	0.9714 mL	4.8568 mL
50 mM	0.0389 mL	0.1943 mL	0.3885 mL	1.9427 mL
100 mM	0.0194 mL	0.0971 mL	0.1943 mL	0.9714 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc