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Bupivacaine hydrochloride

Name: Bupivacaine hydrochloride
Brand: TargetMol
SKU: T0030
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0030Cas No. 18010-40-7

Alias Vivacaine, Bupivacaine HCl

Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.

Bupivacaine hydrochloride

🥰Excellent

Purity: 99.9%

Catalog No. T0030Alias Vivacaine, Bupivacaine HClCas No. 18010-40-7

Pack Size	Price	Availability
100 mg	$35	In Stock
200 mg	$39	In Stock
500 mg	$53	In Stock
1 g	$77	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.9%

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	Bupivacaine hydrochloride (Vivacaine) is a long-acting, amide-type local anesthetic. Bupivacaine hydrochloride reversibly binds to specific sodium ion channels in the neuronal membrane, resulting in a decrease in the voltage-dependent membrane permeability to sodium ions and membrane stabilization; inhibition of depolarization and nerve impulse conduction; and a reversible loss of sensation.
In vitro	Bupivacaine can induce calcium release from the sarcoplasmic reticulum (SR) in rats and suppress the SR's uptake of calcium.
In vivo	In vitro, Bupivacaine exhibits cytotoxic effects on bovine articular chondrocytes after an exposure of 15 to 30 minutes. It acts on isolated mitochondria as an uncoupler of oxygen consumption and adenosine diphosphate phosphorylation. Concentration-dependent mitochondrial depolarization and pyridine nucleotide oxidation are induced by Bupivacaine in these isolated mitochondria. Additionally, Bupivacaine triggers the opening of the permeability transition pore (PTP), a cyclosporin A-sensitive inner membrane channel pivotal in various forms of cell death.
Synonyms	Vivacaine, Bupivacaine HCl

Chemical Properties

Molecular Weight	324.89
Formula	C₁₈H₂₈N₂O·HCl
Cas No.	18010-40-7
Smiles	Cl.CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16.67 mg/mL (51.31 mM), Sonication is recommended.

H2O: 21 mg/mL (64.64 mM), Sonication is recommended.

Ethanol: 60 mg/mL (184.68 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.16 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O/Ethanol

	1mg	5mg	10mg	50mg
1 mM	3.0780 mL	15.3898 mL	30.7796 mL	153.8982 mL
5 mM	0.6156 mL	3.0780 mL	6.1559 mL	30.7796 mL
10 mM	0.3078 mL	1.5390 mL	3.0780 mL	15.3898 mL
20 mM	0.1539 mL	0.7695 mL	1.5390 mL	7.6949 mL
50 mM	0.0616 mL	0.3078 mL	0.6156 mL	3.0780 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc