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Anti-RIM2 Polyclonal Antibody
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Catalog No. TMAB-12257
Anti-RIM2 Polyclonal Antibody is a Rabbit antibody targeting RIM2. Anti-RIM2 Polyclonal Antibody can be used in FCM.
Anti-RIM2 Polyclonal Antibody
Anti-RIM2 Polyclonal Antibody
😃Good
Catalog No. TMAB-12257
Anti-RIM2 Polyclonal Antibody is a Rabbit antibody targeting RIM2. Anti-RIM2 Polyclonal Antibody can be used in FCM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $221 | 7-10 days | 7-10 days | |
| 100 μL | $373 | 7-10 days | 7-10 days | |
| 200 μL | $527 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-RIM2 Polyclonal Antibody is a Rabbit antibody targeting RIM2. Anti-RIM2 Polyclonal Antibody can be used in FCM. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Chicken,Dog,Cow,Horse,Rabbit,Sheep) |
| Application | |
| Recommended Dose | FCM: 3μg/Test |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Peripheral membrane protein (By similarity). Cell junction, synapse (By similarity). Cell junction, synapse, presynaptic cell membrane; Peripheral membrane protein (By similarity). |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Rab3, a neural/neuroendocrine-specific member of the Rab family, is involved in Ca2+-regulated exocytosis (1-2). Rab3 functions in an inhibitory capacity by controlling the recruitment of secretory vesicles into a releasable pool at the plasma membrane. Rim (rab3 interacting molecule), a putative effector protein for Rab3s, is composed of an amino-terminal zinc-finger motif and carboxy-terminal PDZ and C2 domains. Rim exists as two variants, Rim1 and Rim2, produced by alternative splicing (3). Rim1 is expressed near the active zone at the synapse, where it interacts in a GTP-dependent manner with Rab3, located on synaptic vesicles (4). Therefore, Rim serves as a Rab3-dependent regulator of synaptic-vesicle fusion by forming a GTP-dependent complex between synaptic plasma membranes and docked synaptic vesicles (5). Both Rim1 and Rim2 can bind to cAMP-GEFII, which is a direct target of cAMP in regulated exocytosis and is responsible for cAMP-dependent, PKA-dependent exocytosis (3). Rim also localizes on the plasma membrane of INS-1E cells and pancreatic beta-cells. Rab3 binding domain of Rim enhances glucose-stimulated secretion in intact cells and Ca2+-stimulated exocytosis in permeabilized cells, suggesting that Rim may also play a regulatory role in insulin secretion (6). |
| Immunogen | KLH conjugated synthetic peptide: human RIM2 |
| Antigen Species | Human |
| Gene Name | RIMS2 |
| Gene ID | |
| Protein Name | Regulating synaptic membrane exocytosis protein 2 |
| Uniprot ID | |
| Function | RIM2 is a rab effector involved in exocytosis. It may act as scaffold protein. It is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP dependent manner. |
| Molecular Weight | Theoretical: 160 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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