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VU0360172

Name: VU0360172
Brand: TargetMol
SKU: T29126
Price: 52 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T29126Cas No. 1310012-12-4

Alias VU-0360172, VU 0360172

VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).

VU0360172

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Purity: 99.56%

Catalog No. T29126Alias VU-0360172, VU 0360172Cas No. 1310012-12-4

VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).

Pack Size	Price	Availability
1 mg	$52	In Stock
5 mg	$123	In Stock
10 mg	$197	In Stock
25 mg	$396	In Stock
50 mg	$619	In Stock
100 mg	$877	In Stock
1 mL x 10 mM (in DMSO)	$117	In Stock

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Batch Information

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Purity:99.56%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).
Targets&IC50	mGlu5:195 nM(Ki), mGlu5:16 nM(EC50)
In vivo	VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[4].
Synonyms	VU-0360172, VU 0360172

Chemical Properties

Molecular Weight	294.32
Formula	C₁₈H₁₅FN₂O
Cas No.	1310012-12-4
Smiles	Fc1cccc(c1)C#Cc1ccc(cn1)C(=O)NC1CCC1
Relative Density.	1.27 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83 mg/mL (282.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3977 mL	16.9883 mL	33.9766 mL	169.8831 mL
5 mM	0.6795 mL	3.3977 mL	6.7953 mL	33.9766 mL
10 mM	0.3398 mL	1.6988 mL	3.3977 mL	16.9883 mL
20 mM	0.1699 mL	0.8494 mL	1.6988 mL	8.4942 mL
50 mM	0.0680 mL	0.3398 mL	0.6795 mL	3.3977 mL
100 mM	0.0340 mL	0.1699 mL	0.3398 mL	1.6988 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc