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Handelin
😃Good
Catalog No. TN1131Cas No. 62687-22-3
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
Handelin
😃Good
Purity: 99.34%
Catalog No. TN1131Cas No. 62687-22-3
Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $64 | In Stock | In Stock | |
| 5 mg | $178 | In Stock | In Stock | |
| 10 mg | $297 | In Stock | In Stock | |
| 25 mg | $492 | In Stock | In Stock | |
| 50 mg | $718 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $236 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Batch Information
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Purity:99.34%
Appearance:Solid
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Handelin has anti-inflammatory activity by inhibiting NF-κB activation and pro-inflammatory cytokine productions. |
| In vitro | The present study was designed to investigate the anti-inflammatory potential of Handelin in vitro and in vivo. Handelin inhibited LPS-stimulated production of NO and PGE2 in cultured mouse macrophage RAW 264.7 cells. The suppression of NO and PGE2 production by Handelin was correlated with the down-regulation of mRNA and protein expressions of iNOS and COX-2. Further study revealed that Handelin suppressed the induction of pro-inflammatory cytokines including TNF-α± and IL-1β as well as microRNA-155 in LPS-induced RAW264.7 cells. Activation of the transcriptional activity of NF-κB by LPS was also alleviated by Handelin, which was well coincided with its inhibitory effect on IκB degradation. In addition, the activation of MAPKs such as ERK and JNK signaling was suppressed by Handelin. In in vivo animal model, oral administration of Handelin inhibited carrageenan-induced paw edema and TPA-induced ear edema, respectively. The analysis of cytokine production in serum showed that Handelin dose-dependently inhibited the production of IL-1β in a carrageenan-induced paw edema. |
| Molecular Weight | 552.66 |
| Formula | C32H40O8 |
| Cas No. | 62687-22-3 |
| Smiles | [H][C@@]12CC[C@@](C)(O)[C@]34C[C@@]5(C(=O)O[C@@]6([H])[C@@]5([H])[C@H](C[C@@](C)(O)[C@]5([H])CC=C(C)[C@]65[H])OC(C)=O)[C@](C)(C=C3)[C@@]4([H])[C@]1([H])OC(=O)C2=C |
| Relative Density. | 1.34 g/cm3 at 20℃ |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 10 mg/mL (18.09 mM), Sonication is recommended.  | ||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+90% Corn Oil: 1 mg/mL (1.81 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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