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TargetMol | Compound Library

Tyrosine Kinase Inhibitor Library

Catalog No. L2200

A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved in signal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis. More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis.

The Tyrosine Kinase Inhibitors Library by TargetMol, containing 1120 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2200

Tyrosine Kinase Inhibitor Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 1120 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

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Library Customization | TargetMol Library Composition

EGFR
VEGFR
Apoptosis
JAK
Src
FLT
PDGFR
Autophagy
FGFR
c-Kit
c-Met/HGFR
Bcr-Abl
ALK
PKA
Tyrosine Kinases
CDK
IGF-1R
c-RET
FAK
TAM Receptor
Trk receptor
HER
c-Fms
Syk
Potassium Channel
Aurora Kinase
PKC
DYRK
Raf
Akt
BTK
TGF-beta/Smad
Ephrin Receptor
ERK
ROS Kinase
CSF-1R
STAT
NF-κB
p38 MAPK
S6 Kinase
GSK-3
Endogenous Metabolite
Discoidin Domain Receptor (DDR)
PI3K
5-HT Receptor
Antibacterial
ROS
TNF
Tie-2
PYK2
ROCK
mTOR
JNK
Serine/threonin kinase
Calcium Channel
Chk
MAPK
MEK
PROTACs
Ferroptosis
Cytochromes P450
Casein Kinase
IκB/IKK
Microtubule Associated
Antibiotic
HIV Protease
Drug Metabolite
ACK1
COX
Influenza Virus
HDAC
Sodium Channel
Tyrosinase
MLK
Antifungal
Histamine Receptor
Mitophagy
Parasite
Pim
Caspase
RIP kinase
PDE
Reactive Oxygen Species
CaMK
DNA/RNA Synthesis
SARS-CoV
Beta Amyloid
SGK
AChR
Histone Methyltransferase
HCV Protease
Ligands for Target Protein for PROTAC
Virus Protease
Hck
Adrenergic Receptor
MAO
IL Receptor
MNK
Antiviral
HSP
TLR
Bcl-2 Family
PDK
AMPK
Phospholipase
PLK
IRAK
Dehydrogenase
Antioxidant
Adenosine Receptor
IFNAR
Phosphatase
PPAR
Topoisomerase
Myosin
IRE1
LDL
GRK
MMP
GluR
Interleukin
Sigma receptor
p53
NO Synthase
IKZF
Melanin-concentrating Hormone Receptor (MCHR)
GPCR
Carbonic Anhydrase
DHFR
GDNF
ROR
DNA-PK
Integrin
YAP
Na+/Ca2+ Exchanger
NADPH
GTPase
HBV
Wnt/beta-catenin
Rho
Serine Protease
Antifolate
Serotonin Transporter
Cell Cycle Arrest
Nucleoside Antimetabolite/Analog
LIM Kinase
Glucokinase
NAMPT
E1/E2/E3 Enzyme
Haspin Kinase
NMDAR
Mitochondrial Metabolism
Monoamine Transporter
DNA Alkylation
Hedgehog/Smoothened
FAAH
HSV
CCR
PAD
Epigenetic Reader Domain
Lipoxygenase
Norepinephrine
DUB
Wee1
BCRP
P-gp
Prostaglandin Receptor
LRRK2
Sirtuin
Histone Acetyltransferase
transporter
PAI-1
MELK
RSV
Hippo pathway
Reverse Transcriptase
Protease
CRISPR/Cas9
HIF
Gap Junction Protein
DAPK
Anti-infection
NADPH-oxidase
p97
HIF/HIF Prolyl-Hydroxylase
IGF-2R