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TargetMol | Compound Library

Tyrosine Kinase Inhibitor Library

Catalog No. L2200

A protein kinase is a kinase enzyme that modifies other molecules, mostly proteins, by chemically adding phosphate groups to them (phosphorylation) to regulate the majority of cellular pathways, especially those involved in signal transduction. Phosphorylation usually results in a functional change of the target protein (substrate) by changing enzyme activity, cellular location, or association with other proteins. Of the 518 known kinases, the most successful class for drug targeting is the tyrosine kinase family consisting of 90 distinct and diverse members. Abnormal expression of PTK usually leads to cell proliferation disorders, and is closely related to tumor invasion, metastasis and tumor angiogenesis. More recently, PTKs play a pivotal role in inflammatory diseases such as idiopathic pulmonary fibrosis.

The Tyrosine Kinase Inhibitors Library by TargetMol, containing 1120 tyrosine kinase inhibitors, can be used for research in tyrosine kinase signaling, and drug screening for related diseases.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L2200

Tyrosine Kinase Inhibitor Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

Product Description Product Description

  • A unique collection of 1120 tyrosine kinase inhibitors for high throughput screening and high content screening for drug discovery in tyrosine kinase related diseases;
  • Bioactivity and safety confirmed by pre-clinical research and clinical trials, and some of them are approved by FDA;
  • Targets include c-Kit, c-Met, EGFR, FGFR, SRC, JAK, SYK, Btk, Bcr-Abl, etc;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description;
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

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Library Customization | TargetMol Library Composition

EGFR
Apoptosis
VEGFR
JAK
Src
FLT
Autophagy
PDGFR
FGFR
c-Met/HGFR
c-Kit
Bcr-Abl
ALK
PKA
Tyrosine Kinases
CDK
IGF-1R
FAK
c-RET
c-Fms
TAM Receptor
Trk receptor
HER
TGF-beta/Smad
Akt
Potassium Channel
Syk
Aurora Kinase
Raf
PKC
DYRK
BTK
ERK
STAT
Ephrin Receptor
Endogenous Metabolite
ROS Kinase
p38 MAPK
NF-κB
CSF-1R
S6 Kinase
PI3K
GSK-3
Antibacterial
Discoidin Domain Receptor (DDR)
5-HT Receptor
mTOR
Tie-2
PYK2
Caspase
ROCK
MEK
ROS
TNF
Serine/threonin kinase
Reactive Oxygen Species
JNK
Calcium Channel
Drug Metabolite
Influenza Virus
Microtubule Associated
Parasite
Cytochromes P450
Casein Kinase
Chk
MAPK
Ferroptosis
Antibiotic
Tyrosinase
PROTACs
Virus Protease
HIV Protease
IκB/IKK
ACK1
COX
DNA/RNA Synthesis
MLK
HDAC
Ligands for Target Protein for PROTAC
Sodium Channel
Mitophagy
SARS-CoV
RIP kinase
Pim
CaMK
Beta Amyloid
SGK
Phosphatase
PDE
Antifungal
Bcl-2 Family
Histamine Receptor
AMPK
AChR
Histone Methyltransferase
Hck
Adrenergic Receptor
Antiviral
PDK
HCV Protease
TLR
IL Receptor
MNK
PLK
Ras
PARP
MAO
IRAK
Interleukin
HSP
Phospholipase
Wee1
Dehydrogenase
IFNAR
GRK
Anti-infection
Monoamine Oxidase
Topoisomerase
IRE1
LDL
Prostaglandin Receptor
p53
NO Synthase
Antioxidant
HSV
GluR
Sigma receptor
PPAR
Serine Protease
MMP
GPCR
Adenosine Receptor
PAK
Reverse Transcriptase
Integrin
Myosin
IKZF
Estrogen/progestogen Receptor
Antifolate
PAD
BCRP
DAPK
p97
YAP
NADPH
Telomerase
transporter
Proton pump
FXR
Norepinephrine
P-gp
LRRK2
NADPH-oxidase
Carbonic Anhydrase
GDNF
PERK
HBV
Wnt/beta-catenin
Nucleoside Antimetabolite/Analog
iGluR
E1/E2/E3 Enzyme
Monoamine Transporter
FAAH
CCR
Sirtuin
cGAS
Hippo pathway
Kras
CRISPR/Cas9
Hydroxylase
ROR
Cell Cycle Arrest
LIM Kinase
Glucokinase
Haspin Kinase
Gamma-secretase
NMDAR
Mitochondrial Metabolism
Angiotensin-converting Enzyme (ACE)
DUB
RSV
Protease
HIF/HIF Prolyl-Hydroxylase
Na+/Ca2+ Exchanger
GTPase
c-Myc
Rho
NAMPT
Lipoxygenase
Histone Acetyltransferase
PAI-1
MELK
GABA Receptor
HIF
MDM-2/p53
Gap Junction Protein
Melanin-concentrating Hormone Receptor (MCHR)
DHFR
DNA-PK
Estrogen Receptor/ERR
Serotonin Transporter
Hedgehog/Smoothened
DNA Alkylation
Epigenetic Reader Domain
IGF-2R