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T16Ainh-A01

Name: T16Ainh-A01
Brand: TargetMol
SKU: T13059
Price: 35 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13059Cas No. 552309-42-9

T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 μM),and functions as a calcium-activated chloride channel (CaCC).

T16Ainh-A01

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Purity: 98.15%

Catalog No. T13059Cas No. 552309-42-9

T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 μM),and functions as a calcium-activated chloride channel (CaCC).

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$35	In Stock	In Stock
10 mg	$63	In Stock	In Stock
25 mg	$139	In Stock	In Stock
50 mg	$237	In Stock	In Stock
100 mg	$378	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$39	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.15%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	T16Ainh-A01 is a potent inhibitor of TMEM16A Chloride channel, inhibiting TMEM16A-mediated chloride currents (IC50 of 1 μM),and functions as a calcium-activated chloride channel (CaCC).
Targets&IC50	TMEM16A (Cl- channel):1 µM
In vitro	T16Ainh-A01 (0.3-30μM) can significantly reduce the inward and outward components of IClCa and inhibit IClCa in RUICC without significantly affecting L-type Ca2+ current[1]. T16Ainh-A01 (10 μM) inhibits nearly completely TMEM16A chloride current (induced by 275 nM free calcium in the pipette) at all voltages, indicating a voltage-independent block mechanism[2].

Chemical Properties

Molecular Weight	416.52
Formula	C₁₉H₂₀N₄O₃S₂
Cas No.	552309-42-9
Smiles	CCc1c(C)[nH]c(SCC(=O)Nc2nc(cs2)-c2ccc(OC)cc2)nc1=O
Relative Density.	1.39 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMF: 10 mg/mL (24.01 mM), Sonication is recommended.

DMSO: 83.33 mg/mL (200.06 mM), Sonication is recommended.

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4008 mL	12.0042 mL	24.0085 mL	120.0423 mL
5 mM	0.4802 mL	2.4008 mL	4.8017 mL	24.0085 mL
10 mM	0.2401 mL	1.2004 mL	2.4008 mL	12.0042 mL
20 mM	0.1200 mL	0.6002 mL	1.2004 mL	6.0021 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0480 mL	0.2401 mL	0.4802 mL	2.4008 mL
100 mM	0.0240 mL	0.1200 mL	0.2401 mL	1.2004 mL

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline /PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Stock solution preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline /PBS/ddH₂O TargetMol | reagent

mix well and clarify

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