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Propiconazole (PRO) is an orally active brassinosteroid biosynthesis inhibitor and a triazole fungicide with antifungal activity.

| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 mg | $42 | - | In Stock | |
| 100 mg | $68 | - | In Stock | |
| 200 mg | $98 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | - | In Stock |
| Description | Propiconazole (PRO) is an orally active brassinosteroid biosynthesis inhibitor and a triazole fungicide with antifungal activity. |
| In vivo | Methods: Propiconazole (10, 75, 150 mg/kg, gavage, 14 days) was used to treat male Sprague-Dawley rats and male CD-1 mice to study the effects of propiconazole on hepatic cytochrome P450 gene expression and P450 enzyme activity in vivo; quantitative real-time RT-PCR was performed on rat liver RNA samples from animals treated with 150 mg/kg body weight/day. Results: Compared with the control, the mRNA of the following genes was significantly overexpressed: CYP1A2 (1.62-fold), CYP2B1 (10.8-fold), CYP3A1/CYP3A23 (2.78-fold), and CYP3A2 (1.84-fold); in mouse liver, propiconazole produced mRNA overexpression of Cyp2b10 (2.39-fold) and Cyp3a11 (5.19-fold); propiconazole significantly induced hexanoresorufin O-dealkylation (PROD) and methoxymethasone O-dealkylation (MROD) activities in rat and mouse livers at doses of 150 mg/kg and 75 mg/kg.[4] |
| Synonyms | Desmel, CGA-64250, CGA64250 |
| Molecular Weight | 342.22 |
| Formula | C15H17Cl2N3O2 |
| Cas No. | 60207-90-1 |
| Smiles | ClC1=CC=C(C(Cl)=C1)C2(OCC(O2)CCC)CN3N=CN=C3 |
| Relative Density. | 1.2700 g/cm3 |
| Color | Transparent |
| Appearance | Viscous |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (233.77 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.64 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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