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RKI1313

Name: RKI1313
Brand: TargetMol
SKU: T2011
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2011Cas No. 1342276-76-9

Alias RKI-1313, RKI 1313

RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.

RKI1313

🥰Excellent

Purity: 99.53%

Catalog No. T2011Alias RKI-1313, RKI 1313Cas No. 1342276-76-9

RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.

Pack Size	Price	Availability
500 μg	$45	In Stock
1 mg	$64	In Stock
5 mg	$145	In Stock
10 mg	$218	In Stock
25 mg	$388	In Stock
50 mg	$568	In Stock
100 mg	$812	In Stock
1 mL x 10 mM (in DMSO)	$163	In Stock

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Batch Information

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Purity:99.53%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	RKI1313 (RKI-1313) was a selective inhibitor for ROCK-dependent signaling, cytoskeletal changes, anchorage-independent colony formation, migration, and invasion.
Targets&IC50	ROCK1:34 μM, ROCK2:8 μM
Synonyms	RKI-1313, RKI 1313

Chemical Properties

Molecular Weight	340.4
Formula	C₁₇H₁₆N₄O₂S
Cas No.	1342276-76-9
Smiles	N(C(NCC1=CC(OC)=CC=C1)=O)C2=NC(=CS2)C=3C=CN=CC3
Relative Density.	1.323 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (161.57 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9377 mL	14.6886 mL	29.3772 mL	146.8860 mL
5 mM	0.5875 mL	2.9377 mL	5.8754 mL	29.3772 mL
10 mM	0.2938 mL	1.4689 mL	2.9377 mL	14.6886 mL
20 mM	0.1469 mL	0.7344 mL	1.4689 mL	7.3443 mL
50 mM	0.0588 mL	0.2938 mL	0.5875 mL	2.9377 mL
100 mM	0.0294 mL	0.1469 mL	0.2938 mL	1.4689 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc