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Corydaline
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Catalog No. T5S2360Cas No. 518-69-4
Alias Corydalin, (+)-Corydaline
1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation. 3. Corydaline exhibits the anti-acetylcholinesterase, antiallergic, and antinociceptive activities. 4. Corydaline has potent inhibition of CYP2C19 and CYP2C9.
Corydaline
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Purity: 99.86%
Catalog No. T5S2360Alias Corydalin, (+)-CorydalineCas No. 518-69-4
1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation. 3. Corydaline exhibits the anti-acetylcholinesterase, antiallergic, and antinociceptive activities. 4. Corydaline has potent inhibition of CYP2C19 and CYP2C9.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 5 mg | $55 | In Stock | In Stock | |
| 10 mg | $89 | In Stock | In Stock | |
| 25 mg | $148 | In Stock | In Stock | |
| 50 mg | $219 | - | In Stock | |
| 100 mg | $326 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $61 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.86%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Corydaline AI Summary
Corydaline is an inhibitor displaying diverse bioactivities across various assays. It inhibits electric eel AChE by 13.9% and horse BChE by -0.53% at a concentration of 2 mg/ml. The compound also shows a permeability of -4.93 log Pe at 100 µM after 4 hours, as determined by the PAMPA-BBB assay. Additionally, it inhibits Clostridium perfringens neuraminidase enzyme by 12.7% at 100 µM. In terms of antiparasitic activity, it has an IC50 of 19952.62 nM in Leishmania donovani imaging for infected macrophages, and an IC50 of greater than 50118.72 nM in H9c2 host cardiomyocytes for Trypanosoma cruzi. For Leishmania donovani imaging of amastigotes/macrophages, the IC50 is 15848.93 nM, while for THP-1 host macrophages for Leishmania donovani, the IC50 exceeds 50118.72 nM. The compound exhibits an IC50 of 25118.86 nM in a Trypanosoma brucei viability assay using fluorescence intensity, whereas in the luminiscence assay, the IC50 is greater than 39810.72 nM. For the HepG2 human cell line viability assay using luminiscence, the IC50 is greater than 100000.0 nM. Additionally, Corydaline has an IC50 of 25118.86 nM in a Trypanosoma cruzi viability assay using beta-GAL activity and an IC50 of 79432.82 nM in CYP51 from Trypanosoma cruzi. In Trypanosoma cruzi imaging of amastigotes/cells, the IC50 is 19952.62 nM, and in Leishmania donovani viability assay using fluorescence intensity, the IC50 is 2511.89 nM..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Corydaline (Corydalin), an isoquinoline alkaloid, is one of the major active constituents in a new prokinetic botanical agent. 2. Corydaline promotes gastric emptying and small intestinal transit and facilitates gastric accommodation. 3. Corydaline exhibits the anti-acetylcholinesterase, antiallergic, and antinociceptive activities. 4. Corydaline has potent inhibition of CYP2C19 and CYP2C9. |
| Targets&IC50 | Enterovirus 71:25.23 µM (IC50), μ opioid receptor:1.23 µM (Ki), AChE:226 µM (IC50) |
| Synonyms | Corydalin, (+)-Corydaline |
| Molecular Weight | 369.45 |
| Formula | C22H27NO4 |
| Cas No. | 518-69-4 |
| Smiles | COc1cc2CCN3Cc4c(ccc(OC)c4OC)C(C)C3c2cc1OC |
| Relative Density. | 1.1771 g/cm3 (Estimated) |
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 137.5 mg/mL (372.17 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.41 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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