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IA-Alkyne

Name: IA-Alkyne
Brand: TargetMol
SKU: T15543
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15543Cas No. 930800-38-7

Alias N-Hex-5-ynyl-2-iodo-acetamide, Iodoacetamide-alkyne

IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of respiratory infection.

IA-Alkyne

🥰Excellent

Purity: 99.76%

Catalog No. T15543Alias N-Hex-5-ynyl-2-iodo-acetamide, Iodoacetamide-alkyneCas No. 930800-38-7

Pack Size	Price	Availability
1 mg	$54	In Stock
5 mg	$128	In Stock
10 mg	$197	In Stock
25 mg	$277	In Stock
50 mg	$347	In Stock
100 mg	$479	In Stock
1 mL x 10 mM (in DMSO)	$123	In Stock

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Batch Information

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Purity:99.76%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	IA-Alkyne (Iodoacetamide-alkyne) is a TRP channel (TRPC) agonist. IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling. It also has the potential for the study of respiratory infection.
In vitro	IA-alkyne (2.5-10 μM; 1 hour) reacts with cysteines. In-gel fluorescence imaging indicates strong fluorescent intensity of IA-alkyne. Labeled proteome samples are conjugated with a fluorescent rhodamine-azide tag via CuAAC and analyzed by SDS-PAGE. Soluble fractions of HeLa cell lysates (2.0 mg/ml) are treated with IA-alkyne [2].
Synonyms	N-Hex-5-ynyl-2-iodo-acetamide, Iodoacetamide-alkyne

Chemical Properties

Molecular Weight	265.09
Formula	C₈H₁₂INO
Cas No.	930800-38-7
Smiles	C(NC(CI)=O)CCCC#C
Relative Density.	1.567 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (207.48 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (7.54 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7723 mL	18.8615 mL	37.7230 mL	188.6152 mL
5 mM	0.7545 mL	3.7723 mL	7.5446 mL	37.7230 mL
10 mM	0.3772 mL	1.8862 mL	3.7723 mL	18.8615 mL
20 mM	0.1886 mL	0.9431 mL	1.8862 mL	9.4308 mL
50 mM	0.0754 mL	0.3772 mL	0.7545 mL	3.7723 mL
100 mM	0.0377 mL	0.1886 mL	0.3772 mL	1.8862 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc