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Platicodigenin

Name: Platicodigenin
Brand: TargetMol
SKU: TMS0943
Price: 71 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TMS0943Cas No. 22327-82-8

Alias Platycodigenin

Platicodigenin (Platycodigenin) isolated from platycodon grandiflorum, has in vitro anti-proliferative activity against the HSC-T6 cell line.

Platicodigenin

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Purity: 98.61%

Catalog No. TMS0943Alias PlatycodigeninCas No. 22327-82-8

Platicodigenin (Platycodigenin) isolated from platycodon grandiflorum, has in vitro anti-proliferative activity against the HSC-T6 cell line.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$71	In Stock	In Stock
5 mg	$179	In Stock	In Stock
10 mg	$268	In Stock	In Stock
25 mg	$453	In Stock	-
1 mL x 10 mM (in DMSO)	$142	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:98.61%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	Platicodigenin (Platycodigenin) isolated from platycodon grandiflorum, has in vitro anti-proliferative activity against the HSC-T6 cell line.
In vitro	Two new oleanane-type triterpenoids, named platycodonoids A and B (1, 2), together with five known saponins, including platycodin D (3), deapioplatycodin D (4), 3-O-β-D-glucopyranosyl polygalacic acid (5), 3-O-β-D-glucopyranosyl Platycodigenin (6) and polygalacin D (7), were isolated from the roots of Platycodon grandiflorum. METHODS AND RESULTS: On the basis of spectral data and chemical evidence, the structures of the new compounds were elucidated as 2β,3β,23,24-tetrahydroxy-28-nor-olean-12-en-16-one (1) and 2β,3β,23,24- tetrahydroxy-28-nor-olean-12-en-16-one-3-O-β-D-glucopyranoside (2). Compounds 1-7 were evaluated for their in vitro anti-proliferative activity against the HSC-T6 cell line.
Synonyms	Platycodigenin

Chemical Properties

Molecular Weight	520.7
Formula	C₃₀H₄₈O₇
Cas No.	22327-82-8
Smiles	[H][C@@]12CC(C)(C)CC[C@@]1([C@H](O)C[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)C[C@H](O)[C@H](O)C(CO)(CO)[C@]3([H])CC[C@@]12C)C(O)=O
Relative Density.	1.28 g/cm3 at 20℃

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (115.23 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9205 mL	9.6025 mL	19.2049 mL	96.0246 mL
5 mM	0.3841 mL	1.9205 mL	3.8410 mL	19.2049 mL
10 mM	0.1920 mL	0.9602 mL	1.9205 mL	9.6025 mL
20 mM	0.0960 mL	0.4801 mL	0.9602 mL	4.8012 mL
50 mM	0.0384 mL	0.1920 mL	0.3841 mL	1.9205 mL
100 mM	0.0192 mL	0.0960 mL	0.1920 mL	0.9602 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc