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Anti-L-selectin Antibody-FITC (8M356)
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Catalog No. TMAY-02088F
Alias selectin L
Anti-L-selectin Antibody-FITC (8M356) is a FITC-conjugated Rabbit antibody targeting L-selectin. Anti-L-selectin Antibody-FITC (8M356) can be used in FCM.
Anti-L-selectin Antibody-FITC (8M356)
Anti-L-selectin Antibody-FITC (8M356)
😃Good
Catalog No. TMAY-02088FAlias selectin L
Anti-L-selectin Antibody-FITC (8M356) is a FITC-conjugated Rabbit antibody targeting L-selectin. Anti-L-selectin Antibody-FITC (8M356) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 T | $80 | 7-10 days | |
| 100 T | $175 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: FCM Reactivity: Human |
| Alias | selectin L |
| Ig Type | Rabbit IgG |
| Clone | 8M356 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human SELL(CD62L) expression on human whole blood lymphocytes. Cells were stained with FITC-conjugated anti-Human SELL(CD62L). The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human SELL / CD62L (rh SELL / CD62L; TMPY-02024; P14151-1; Met1-Asn332) and conjugated with FITC under optimum conditions, the unreacted FITC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.03%ProClin300 |
| Research Background | L-selectin (SELL), also known as CD62L, is a key adhesion molecule that regulates both the migration of leukocytes at sites of inflammation and the recirculation of lymphocytes between blood and lymphoid tissues. It belongs to the selectin family of proteins, and consisting of a large, highly glycosylated, extracellular domain, a single spanning transmembrane domain and a small cytoplasmic tail. L-selectin is the only selectin expressed on leukocytes and mediates a number of leukocyte-endothelial interactions. L-selectin acts as a "homing receptor" for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point. L-selectin-mediated lymphocyte recirculation is required for maintaining the appropriate tissue distribution of lymphocyte subpopulations including naïve and effector subsets such as regulatory T cells. In addition, L-selectin-mediated entry into peripheral lymph nodes is required for optimal induction of lymphocyte homeostatic proliferation during lymphopenia. Importantly, L-selectin has been shown to have both adhesive and signaling functions during leukocyte migration. L-selectin has also been shown to mediate leukocyte recruitment during chronic inflammatory and autoimmune diseases and thus is a potential therapeutic target for drug development. |
| Conjucates | FITC |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | Recombinant Protein: Human SELL / CD62L Protein (TMPY-02024) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. |
| Transport | Shipping with blue ice. |
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