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Oxethazaine

Name: Oxethazaine
Brand: TargetMol
SKU: T0044
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0044Cas No. 126-27-2

Alias Oxetacaine

Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain.

Oxethazaine

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Purity: 99.94%

Catalog No. T0044Alias OxetacaineCas No. 126-27-2

Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$29	In Stock	In Stock
50 mg	Preferential	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$30	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR HPLC

Product Introduction

Oxethazaine AI Summary

Oxethazaine is a bioactive molecule with a diverse profile of inhibitory activities. It effectively inhibits the binding of Batrachotoxinin [3H]BTX-B to high-affinity sites on voltage-dependent sodium channels, with an IC50 value of 2300.0 nM and an inhibition rate of 83.9% at a 10 µM concentration. The compound also targets several enzymes, including Cytochrome P450 2C19, 2D6, and 3A4, and proteins such as Sfp phosphopantetheinyl transferase, 15-hLO, and 15-hLO-2. It demonstrates activity against the importin beta complex dissociation, RanGTP-induced Rango, Polymerase Iota, T. brucei phosphofructokinase, and ATXN expression, and induces DNA re-replication in SW480 colon adenocarcinoma cells. Moreover, Oxethazaine inhibits human tyrosyl-DNA phosphodiesterase 1 both in the presence and absence of CPT and shows potential to block the entry of viruses like Marburg and Ebola Virus. In addition, it functions as a BSEP inhibitor with an IC50 value of less than 10,000.0 nM in regulating ATP-dependent [3H]-taurocholate transport. For antiviral activity, Oxethazaine inhibits SARS-CoV-2 induced cytotoxicity in VERO-6 and Caco-2 cells, albeit with varying effectiveness, showing inhibition rates ranging from 0.21% to 24.59% at a 10 µM concentration. It also exhibits modest inhibition of the SARS-CoV-2 3CL-Pro protease and has IC50 values ranging from 18,600.0 nM to 18,620.87 nM in VERO-E6 cell assays with a CC50 value of 26,300.0 nM, indicating its toxicity limits. In enzymatic studies, Oxethazaine shows inhibitory activity against human HDAC6, achieving 12.09% inhibition with a commercial peptide and 5.97% with a custom peptide. These diverse bioactivities make Oxethazaine a molecule of significant interest across various biological pathways and potential therapeutic applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Oxethazaine (Oxetacaine), a topical anesthetic, is used to prevent acid-induced esophageal pain.
Synonyms	Oxetacaine

Chemical Properties

Molecular Weight	467.64
Formula	C₂₈H₄₁N₃O₃
Cas No.	126-27-2
Smiles	CN(C(=O)CN(CCO)CC(=O)N(C)C(C)(C)Cc1ccccc1)C(C)(C)Cc1ccccc1
Relative Density.	1.093 g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from moisture | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 81.7 mg/mL (174.71 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1384 mL	10.6920 mL	21.3840 mL	106.9199 mL
5 mM	0.4277 mL	2.1384 mL	4.2768 mL	21.3840 mL
10 mM	0.2138 mL	1.0692 mL	2.1384 mL	10.6920 mL
20 mM	0.1069 mL	0.5346 mL	1.0692 mL	5.3460 mL
50 mM	0.0428 mL	0.2138 mL	0.4277 mL	2.1384 mL
100 mM	0.0214 mL	0.1069 mL	0.2138 mL	1.0692 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc