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Anti-HTRA2 Antibody (2I343)

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Catalog No. TMAB-07380

Anti-HTRA2 Antibody (2I343) is a Rabbit antibody targeting HTRA2. Anti-HTRA2 Antibody (2I343) can be used in WB,IHC-P,IHC-Fr,IP,IF.

Anti-HTRA2 Antibody (2I343)

Anti-HTRA2 Antibody (2I343)

😃Good
Catalog No. TMAB-07380
Anti-HTRA2 Antibody (2I343) is a Rabbit antibody targeting HTRA2. Anti-HTRA2 Antibody (2I343) can be used in WB,IHC-P,IHC-Fr,IP,IF.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 μL$1487-10 days7-10 days
50 μL$2637-10 days7-10 days
100 μL$4727-10 days7-10 days
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction

Bioactivity
Description
Anti-HTRA2 Antibody (2I343) is a Rabbit antibody targeting HTRA2. Anti-HTRA2 Antibody (2I343) can be used in WB,IHC-P,IHC-Fr,IP,IF.
Ig Type
IgG
Clone
2I343
Reactivity
Human,Mouse,Rat
Application
Recommended Dose
WB: 1:500-2000; IHC-P: 1:50-200; IHC-Fr: 1:50-200; IP: 1:20-50; IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationMitochondrion intermembrane space. Mitochondrion membrane; Single-pass membrane protein (Potential). Note=Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
Tissue SpecificityIsoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol.
Research BackgroundSerine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Antigen Details
Immunogen
A synthesized peptide: human HTRA2
Antigen Species
Human
Gene Name
HTRA2
Gene ID
Protein Name
Serine protease HTRA2, mitochondrial
Uniprot ID
Function
Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
Chemical Properties
Molecular WeightTheoretical: 49 kDa. Actual: 38 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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