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Cornuside

Name: Cornuside
Brand: TargetMol
SKU: T4S2326
Price: 36 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T4S2326Cas No. 131189-57-6

Alias Comuside, 7-O-Galloylsecologanol, 7-Galloylsecologanol

1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.

Cornuside

🥰Excellent

Purity: 99.86%

Catalog No. T4S2326Alias Comuside, 7-O-Galloylsecologanol, 7-GalloylsecologanolCas No. 131189-57-6

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$36	In Stock	In Stock
5 mg	$58	In Stock	In Stock
10 mg	$88	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$238	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$79	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

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Purity:99.86%

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description

Synonyms

Comuside, 7-O-Galloylsecologanol, 7-Galloylsecologanol

Chemical Properties

Molecular Weight	542.49
Formula	C₂₄H₃₀O₁₄
Cas No.	131189-57-6
Smiles	COC(=O)C1=CO[C@@H](O[C@@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](C=C)[C@@H]1CCOC(=O)c1cc(O)c(O)c(O)c1
Relative Density.	1.58 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 65 mg/mL (119.82 mM), Sonication is recommended.

Pyridine, Methanol, etc.: Soluble

Ethanol: Soluble

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (3.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8434 mL	9.2168 mL	18.4335 mL	92.1676 mL
5 mM	0.3687 mL	1.8434 mL	3.6867 mL	18.4335 mL
10 mM	0.1843 mL	0.9217 mL	1.8434 mL	9.2168 mL
20 mM	0.0922 mL	0.4608 mL	0.9217 mL	4.6084 mL
50 mM	0.0369 mL	0.1843 mL	0.3687 mL	1.8434 mL
100 mM	0.0184 mL	0.0922 mL	0.1843 mL	0.9217 mL

Calculator

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Dilution Calculator
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Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc