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Imgatuzumab (Synonyms: RO 5083945, RG 7160, Anti-EGFR Recombinant Antibody)
Catalog No. T76811 Copy Product Info
Purity: 95%
🥰Excellent
Imgatuzumab (RG 7160; GA201) is a humanized, glycoengineered IgG1 monoclonal antibody targeting the epidermal growth factor receptor (EGFR). This product inhibits EGFR-mediated signaling (such as MAPK and PI3K pathways) by blocking EGF binding and inducing receptor internalization. As a glycoengineered antibody, Imgatuzumab features enhanced affinity for Fc gamma RIIIa, resulting in potent antibody-dependent cellular cytotoxicity (ADCC). It is used to research EGFR-overexpressing solid tumors and demonstrates synergistic effects when combined with chemotherapeutic agents.
Imgatuzumab
Copy Product Info🥰Excellent
Catalog No. T76811
Synonyms RO 5083945, RG 7160, Anti-EGFR Recombinant Antibody
Imgatuzumab (RG 7160; GA201) is a humanized, glycoengineered IgG1 monoclonal antibody targeting the epidermal growth factor receptor (EGFR). This product inhibits EGFR-mediated signaling (such as MAPK and PI3K pathways) by blocking EGF binding and inducing receptor internalization. As a glycoengineered antibody, Imgatuzumab features enhanced affinity for Fc gamma RIIIa, resulting in potent antibody-dependent cellular cytotoxicity (ADCC). It is used to research EGFR-overexpressing solid tumors and demonstrates synergistic effects when combined with chemotherapeutic agents.
Imgatuzumab
Cas No. 959963-46-3
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $247 | - | In Stock | |
| 5 mg | $747 | - | In Stock | |
| 10 mg | $1,200 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:95%
Appearance:Liquid
Color:Transparent
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| Description | Imgatuzumab (RG 7160; GA201) is a humanized, glycoengineered IgG1 monoclonal antibody targeting the epidermal growth factor receptor (EGFR). This product inhibits EGFR-mediated signaling (such as MAPK and PI3K pathways) by blocking EGF binding and inducing receptor internalization. As a glycoengineered antibody, Imgatuzumab features enhanced affinity for Fc gamma RIIIa, resulting in potent antibody-dependent cellular cytotoxicity (ADCC). It is used to research EGFR-overexpressing solid tumors and demonstrates synergistic effects when combined with chemotherapeutic agents. |
| In vitro | Imgatuzumab specifically binds EGFR and exhibits potent ADCC activity in A549 and HCT116 cells. Co-treatment with Gemcitabine, Cisplatin, or Paclitaxel, or pretreatment with Dexamethasone, does not impair Imgatuzumab-mediated ADCC; instead, combination therapies enhance overall anti-tumor efficacy [1]. |
| In vivo | Imgatuzumab significantly inhibits tumor growth in lung and colorectal cancer xenograft mouse models. Combination with Gemcitabine or Paclitaxel leads to enhanced tumor regression and prolonged survival compared to monotherapy, demonstrating synergistic anti-tumor efficacy [1]. |
| Synonyms | RO 5083945, RG 7160, Anti-EGFR Recombinant Antibody |
| Reactivity | Human |
| Application | FACS Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | EGFR |
| Molecular Weight | 145.0 kDa |
| Cas No. | 959963-46-3 |
| Isotype | IgG1 |
| Storage | store at low temperature | store at -20°C | Shipping with blue ice/Shipping at ambient temperature. |
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