Anti-ACVR2B Polyclonal Antibody

Name: Anti-ACVR2B Polyclonal Antibody
Brand: TargetMol
SKU: TMAB-00052
Rating: 4.5 (1 reviews)

(Synonyms: HTX4, ActR-IIB, ACTRIIB, Activin RIIB, activin A receptor, type IIB) Copy Product Info

🥰Excellent

Synonyms: HTX4, ActR-IIB, ACTRIIB, Activin RIIB, activin A receptor, type IIB

Catalog No. TMAB-00052 Copy Product Info

🥰Excellent

Anti-ACVR2B Polyclonal Antibody is a Rabbit antibody targeting ACVR2B. Anti-ACVR2B Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P, WB.

Anti-ACVR2B Polyclonal Antibody

Pack Size	Price	USA Stock	Global Stock
50 μL	$222	7-10 days	7-10 days
100 μL	$372	7-10 days	7-10 days
200 μL	$529	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

Add to Cart

Add to Quotation

For research use only—not for human use. No sales to individuals. Use as intended only.

Questions

Resource Download

Instruction Manual of Detection Antibody

Product Introduction

Bioactivity

Description	Anti-ACVR2B Polyclonal Antibody is a Rabbit antibody targeting ACVR2B. Anti-ACVR2B Polyclonal Antibody can be used in IF, IHC-Fr, IHC-P, WB.
Synonyms	HTX4, ActR-IIB, ACTRIIB, Activin RIIB, activin A receptor, type IIB
Ig Type	IgG
Reactivity	Human,Mouse (predicted:Rat,Dog,Pig,Cow,Sheep)

Application	IF IHC-Fr IHC-P WB
Recommended Dose	WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500
Antibody Type	Polyclonal
Host Species	Rabbit
Subcellular Localization	Cell membrane; Single-pass type I membrane protein.
Construction	Polyclonal Antibody
Purification	Protein A purified
Appearance	Liquid
Formulation	0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration	1 mg/mL
Research Background	Activin receptor type-2B( Activin receptor type IIB; ACTR-IIB ) On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. [Subcellular Location] Membrane; Single-pass type I membrane protein. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Antigen Details

Immunogen	KLH conjugated synthetic peptide: human ACVR2B/ACTR-IIB
Antigen Species	Human
Gene Name	ACVR2B
Gene ID	93
Protein Name	Activin receptor type-2B
Uniprot ID	Q13705
Biology Area	Actin Binding Proteins,Other Kinases,Surface Molecules
Function	Transmembrane serine/threonine kinase activin type-2 receptor forming an activin receptor complex with activin type-1 serine/threonine kinase receptors (ACVR1, ACVR1B or ACVR1c). Transduces the activin signal from the cell surface to the cytoplasm and is thus regulating many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. Activin is also thought to have a paracrine or autocrine role in follicular development in the ovary. Within the receptor complex, the type-2 receptors act as a primary activin receptors (binds activin-A/INHBA, activin-B/INHBB as well as inhibin-A/INHA-INHBA). The type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor.