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Syringin

Name: Syringin
Brand: TargetMol
SKU: T3408
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3408Cas No. 118-34-3

Alias Syringoside, Methoxyconiferine, Lilacin, eleutheroside-b

Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.

Syringin

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Purity: 99.96%

Catalog No. T3408Alias Syringoside, Methoxyconiferine, Lilacin, eleutheroside-bCas No. 118-34-3

Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$45	In Stock	In Stock
10 mg	$63	In Stock	In Stock
25 mg	$121	In Stock	In Stock
50 mg	$157	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.96%

Color:White

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COA HNMR LCMS

Product Introduction

Syringin AI Summary

Syringin exhibits a range of bioactivities across various assays. It demonstrates cytotoxicity against human HeLa, A549, and K562 cells with an IC50 value greater than 5.0 µg/mL and shows bioactivity by inhibiting COX1 with an IC50 value of 36000.0 nM, indicating potential anti-inflammatory properties through the cyclooxygenase enzyme pathway. It also inhibits nitric oxide synthase in mouse J774.1 cells with an observed inhibition rate of 12.3% at 100 µg/mL and shows low potency in inhibiting nitric oxide production in mouse RAW264.7 cells (IC50 > 300,000.0 nM). Additionally, it possesses mild antioxidant activity with a DPPH radical scavenging IC50 value greater than 500,000.0 nM and an EC50 of 70880.0 nM for superoxide radical scavenging. It also exhibits anti-inflammatory effects by inhibiting TNF-alpha production in mouse RAW264.7 cells (IC50 = 34900.0 nM) after LPS stimulation. In assay results, it inhibits AmpC Beta-Lactamase (IC50 = 89125.1 nM) and the RanGTP-induced dissociation of Rango-Importin beta complex (IC50 = 8199.5 nM), as well as displaying inhibition against Marburg Virus entry into cells (IC50 = 20596.2 nM). Furthermore, Syringin shows antifeedant activity against several beetle species, an inhibition rate of 1.8% against Saccharomyces cerevisiae alpha-glucosidase, and potential anti-inflammatory activity in rat polymorphonuclear leukocytes, inhibiting PAF-induced glucuronidase release by less than 30% at 10 µM. Lastly, it demonstrated some capability to inhibit IL-12p40, IL-12, and TNF-alpha production in C57BL/6 mouse BMDCs with moderate potency (IC50 > 50000.0 nM)..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Syringin (eleutheroside-b) is a compound with antitumor, antiproliferative, immunomodulatory and platelet aggregation inhibiting effects.
Synonyms	Syringoside, Methoxyconiferine, Lilacin, eleutheroside-b

Chemical Properties

Molecular Weight	372.37
Formula	C₁₇H₂₄O₉
Cas No.	118-34-3
Smiles	COc1cc(C=CCO)cc(OC)c1OC1OC(CO)C(O)C(O)C1O
Relative Density.	1.2870 g/cm3 (Estimated)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: 12.5 mg/mL (33.57 mM), Sonication is recommended.

DMSO: 250 mg/mL (671.38 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.37 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6855 mL	13.4275 mL	26.8550 mL	134.2750 mL
5 mM	0.5371 mL	2.6855 mL	5.3710 mL	26.8550 mL
10 mM	0.2686 mL	1.3428 mL	2.6855 mL	13.4275 mL
20 mM	0.1343 mL	0.6714 mL	1.3428 mL	6.7138 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0537 mL	0.2686 mL	0.5371 mL	2.6855 mL
100 mM	0.0269 mL	0.1343 mL	0.2686 mL	1.3428 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc