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BAY-474
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Catalog No. T7900Cas No. 1033767-86-0
BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe
BAY-474
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Purity: 98.98%
Catalog No. T7900Cas No. 1033767-86-0
BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $32 | In Stock | In Stock | |
| 5 mg | $68 | In Stock | In Stock | |
| 10 mg | $113 | In Stock | In Stock | |
| 25 mg | $189 | In Stock | In Stock | |
| 50 mg | $283 | In Stock | In Stock | |
| 100 mg | $455 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $81 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.98%
Appearance:Solid
Color:White
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Product Introduction
BAY-474 AI Summary
BAY-474 demonstrates selective bioactivity across various cellular contexts and assays. It significantly promotes cell viability in human fibroblast cells with a growth rate of 1.0 but has no effect on the growth rates of HEK293T and U2OS cell lines. In Hs746T cells, the compound shows a strong inhibitory effect on cell proliferation with an IC90 of 56.0 nM. It also exhibits a potent biochemical affinity for the MET protein, with an IC50 of less than 1.0 nM in the Homogeneous Time Resolved Fluorescence Assay and 2.9 nM for the phosphorylation of MET in NKM-45 cells. Additionally, the compound affects thermal stability or conformation of proteins in a domain-specific manner as indicated by varied Delta TM values. Interaction assays reveal selective binding to the RPS6KA3 enzyme (IC50 of 900.0 nM), PTGER4 (19.0% inhibition), and HTR3A (32.97% control activity). Overall, BAY-474 shows promising domain-specific interactions and selective cellular effects, particularly in enhancing fibroblast viability and inhibiting cell proliferation related to MET targeting in specific cell lines..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe |
| Molecular Weight | 289.33 |
| Formula | C17H15N5 |
| Cas No. | 1033767-86-0 |
| Smiles | Cc1n[nH]c2ccc(cc12)C1C(C#N)=C(C)NC(C)=C1C#N |
| Relative Density. | 1.29 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 120 mg/mL (414.75 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (13.83 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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